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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Asthma


Psychiatry related information on Asthma


High impact information on Asthma


Chemical compound and disease context of Asthma


Biological context of Asthma


Anatomical context of Asthma

  • In bronchial asthma, considerable evidence exists that the eosinophil releases granule proteins, especially the major basic protein (MBP), which in turn mediate tissue abnormalities [24].
  • CONCLUSIONS: This study demonstrates that induced sputum can be used to detect mRNA for TH2 -type cytokines in bronchial asthma and that the increase in IL-4 and IL-5 mRNA expression is similar to that seen with more invasive techniques [25].
  • RESULTS: IL-4-induced expression of CD23 on B cells was greater in normal atopic subjects and atopic patients with bronchial asthma than in normal nonatopic subjects [26].
  • OBJECTIVES: The aim of this study was to investigate the regulatory mechanisms of chemokine production from bronchial epithelium by inflammatory cytokines, especially T(H)2- and T(H)1-derived cytokines, in bronchial asthma [27].
  • These results show that the increased CytOx activity previously reported in skeletal muscle of patients with COPD is also detected in other cell types (such as circulating lymphocytes) and in other chronic inflammatory diseases (such as bronchial asthma and chronic arthritis) [28].

Gene context of Asthma


Analytical, diagnostic and therapeutic context of Asthma


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  3. Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization. Parent, J.L., Labrecque, P., Orsini, M.J., Benovic, J.L. J. Biol. Chem. (1999) [Pubmed]
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  17. Pharmacokinetics and clinical response to single- and multiple-dose sustained-release theophylline compounds in perennial bronchial asthma. Fanta, C.H., McFadden, E.R. Am. J. Med. (1985) [Pubmed]
  18. Bone mineral density and bone turnover in asthmatics treated with long-term inhaled or oral glucocorticoids. Ebeling, P.R., Erbas, B., Hopper, J.L., Wark, J.D., Rubinfeld, A.R. J. Bone Miner. Res. (1998) [Pubmed]
  19. Methylxanthines inhibit exercise-induced bronchoconstriction at low serum theophylline concentration and in a dose-dependent fashion. Magnussen, H., Reuss, G., Jörres, R. J. Allergy Clin. Immunol. (1988) [Pubmed]
  20. Induction of allergen-specific IL-2 responsiveness of lymphocytes after respiratory syncytial virus infection and prediction of onset of recurrent wheezing and bronchial asthma. Noma, T., Mori, A., Yoshizawa, I. J. Allergy Clin. Immunol. (1996) [Pubmed]
  21. Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. Arima, K., Umeshita-Suyama, R., Sakata, Y., Akaiwa, M., Mao, X.Q., Enomoto, T., Dake, Y., Shimazu, S., Yamashita, T., Sugawara, N., Brodeur, S., Geha, R., Puri, R.K., Sayegh, M.H., Adra, C.N., Hamasaki, N., Hopkin, J.M., Shirakawa, T., Izuhara, K. J. Allergy Clin. Immunol. (2002) [Pubmed]
  22. Relationship between total and specific IgE in patients with asthma from Siberia. Gusareva, E.S., Ogorodova, L.M., Chernyak, B.A., Lipoldová, M. J. Allergy. Clin. Immunol. (2008) [Pubmed]
  23. Cat is a major allergen in patients with asthma from west Siberia, Russia. Gusareva, E.S., Bragina, E.J., Deeva, E.V., Kazakevich, N.V., Puzyrev, V.P., Ogorodova, L.M., Lipoldová, M. Allergy. (2006) [Pubmed]
  24. The biology of the eosinophilic leukocyte. Gleich, G.J., Adolphson, C.R., Leiferman, K.M. Annu. Rev. Med. (1993) [Pubmed]
  25. IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: comparison with bronchial wash. Olivenstein, R., Taha, R., Minshall, E.M., Hamid, Q.A. J. Allergy Clin. Immunol. (1999) [Pubmed]
  26. Interleukin-4 and low-affinity receptor for IgE on B cells in peripheral blood of patients with atopic bronchial asthma. Park, C.S., Ra, D.J., Lee, S.M., Jeong, S.W., Uh, S., Kim, H.T., Kim, Y.H. J. Allergy Clin. Immunol. (1996) [Pubmed]
  27. Chemokine production by the BEAS-2B human bronchial epithelial cells: differential regulation of eotaxin, IL-8, and RANTES by TH2- and TH1-derived cytokines. Fujisawa, T., Kato, Y., Atsuta, J., Terada, A., Iguchi, K., Kamiya, H., Yamada, H., Nakajima, T., Miyamasu, M., Hirai, K. J. Allergy Clin. Immunol. (2000) [Pubmed]
  28. The activity of cytochrome oxidase is increased in circulating lymphocytes of patients with chronic obstructive pulmonary disease, asthma, and chronic arthritis. Sauleda, J., García-Palmer, F.J., González, G., Palou, A., Agustí, A.G. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  29. Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse. Sugimoto, T., Ishikawa, Y., Yoshimoto, T., Hayashi, N., Fujimoto, J., Nakanishi, K. J. Exp. Med. (2004) [Pubmed]
  30. Allergen-specific induction of interleukin-2 (IL-2) responsiveness in lymphocytes from children with asthma. I. Antigen specificity and initial events of the induction. Yoshizawa, I., Noma, T., Kawano, Y., Yata, J. J. Allergy Clin. Immunol. (1989) [Pubmed]
  31. Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. Pierzchalska, M., Szabó, Z., Sanak, M., Soja, J., Szczeklik, A. J. Allergy Clin. Immunol. (2003) [Pubmed]
  32. Upregulatory effects of interleukin-4 and interleukin-13 but not interleukin-10 on granulocyte/macrophage colony-stimulating factor production by human bronchial epithelial cells. Nakamura, Y., Azuma, M., Okano, Y., Sano, T., Takahashi, T., Ohmoto, Y., Sone, S. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  33. Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia. Gusareva, E.S., Bragina, E.J., Buinova, S.N., Chernyak, B.A., Puzyrev, V.P., Ogorodova, L.M., Lipoldová, M. Immunol. Lett. (2009) [Pubmed]
  34. IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. Yousefi, S., Hemmann, S., Weber, M., Hölzer, C., Hartung, K., Blaser, K., Simon, H.U. J. Immunol. (1995) [Pubmed]
  35. Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. Penrose, J.F., Spector, J., Baldasaro, M., Xu, K., Boyce, J., Arm, J.P., Austen, K.F., Lam, B.K. J. Biol. Chem. (1996) [Pubmed]
  36. Inhibition of the late asthmatic response by nedocromil sodium administered more than two hours after allergen challenge. Pelikan, Z., Knottnerus, I. J. Allergy Clin. Immunol. (1993) [Pubmed]
  37. Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation. Virchow, J.C., Julius, P., Lommatzsch, M., Luttmann, W., Renz, H., Braun, A. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
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