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Chemical Compound Review

Nilyph     3-propyl-7H-purine-2,6-dione

Synonyms: Enprofilina, Oxeze, ENPROFYLLINE, Enprofyllinum, Lopac-P-5679, ...
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  2. Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation. Nielson, C.P., Crowley, J.J., Cusack, B.J., Vestal, R.E. J. Allergy Clin. Immunol. (1986) [Pubmed]
  3. Adrenergic regulation of lipolysis in fat cells from hyperthyroid and hypothyroid patients. Wahrenberg, H., Wennlund, A., Arner, P. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  4. Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Auchampach, J.A., Jin, X., Wan, T.C., Caughey, G.H., Linden, J. Mol. Pharmacol. (1997) [Pubmed]
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  6. Attenuation of the development of morphine dependence/tolerance by nefiracetam: involvement of adenosine 3':5'-cyclic monophosphate system. Itoh, A., Shiotani, T., Nakayama, S., Mamiya, T., Hasegawa, T., Noda, Y., Nabeshima, T. Behav. Brain Res. (2000) [Pubmed]
  7. Tracheal relaxant and cardiostimulant actions of xanthines can be differentiated from diuretic and CNS-stimulant effects. Role of adenosine antagonism? Persson, C.G., Erjefält, I., Edholm, L.E., Karlsson, J.A., Lamm, C.J. Life Sci. (1982) [Pubmed]
  8. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. Feoktistov, I., Biaggioni, I. J. Clin. Invest. (1995) [Pubmed]
  9. Anti-inflammatory actions of enprofylline, a modified xanthine, in the canine forelimb. Dobbins, D.E., Soika, C.Y., Buehn, M.J., Dabney, J.M. Circ. Res. (1989) [Pubmed]
  10. A comparison of enprofylline and theophylline in the maintenance therapy of chronic reversible obstructive airway disease. Chapman, K.R., Boucher, S., Hyland, R.H., Day, A., Kreisman, H., Rivington, R., Hodder, R.V., York, E.L., Abboud, R.T., Peters, S. J. Allergy Clin. Immunol. (1990) [Pubmed]
  11. Bronchial vs. cardiovascular activities of selective phosphodiesterase inhibitors in the anesthetized beta-blocked dog. Heaslip, R.J., Buckley, S.K., Sickels, B.D., Grimes, D. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  12. Cardiopulmonary effects of enprofylline. A xanthine with weak adenosine receptor antagonism in patients with severe chronic lung disease. Vik-Mo, H., Gulsvik, A., Folling, M. Chest (1988) [Pubmed]
  13. Effects of adenosine and xanthine derivatives on breathing during acute hypoxia in the anesthetized newborn piglet. Darnall, R.A., Bruce, R.D. Pediatr. Pulmonol. (1987) [Pubmed]
  14. Additive bronchodilator effects of terbutaline and enprofylline in asthma. Rasmussen, J.B., Lunell, E. Eur. J. Clin. Pharmacol. (1987) [Pubmed]
  15. Alterations in renal uptake kinetics of the xanthine derivative enprofylline in endotoxaemic mice. Nadai, M., Hasegawa, T., Wang, L., Haghgoo, S., Okasaka, T., Nabeshima, T., Kato, N. J. Pharm. Pharmacol. (1996) [Pubmed]
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  17. Enprofylline kinetics in healthy subjects after single doses. Borgå, O., Andersson, K.E., Edholm, L.E., Fagerström, P.O., Lunell, E., Persson, C.G. Clin. Pharmacol. Ther. (1983) [Pubmed]
  18. The effect of theophylline and enprofylline on allergen-induced bronchoconstriction. Pauwels, R., Van Renterghem, D., Van der Straeten, M., Johannesson, N., Persson, C.G. J. Allergy Clin. Immunol. (1985) [Pubmed]
  19. Cardiovascular effects of two xanthines and the relation to adenosine antagonism. Smits, P., Schouten, J., Thien, T. Clin. Pharmacol. Ther. (1989) [Pubmed]
  20. The effect of theophylline and enprofylline on the late cutaneous response to antigen and compound 48/80. Zunich, K.M., Nelson, H.S., Patel, A., Bodman, S., Gilner, D., Winder, J. J. Allergy Clin. Immunol. (1989) [Pubmed]
  21. Effect of three weeks' treatment with budesonide on in vitro contractile and relaxant airway effects in the rat. Gustafsson, B., Persson, C.G. Thorax (1989) [Pubmed]
  22. The effect of isoenzyme-selective PDE inhibitors on methacholine-induced contraction of guinea-pig and rat ileum. Tomkinson, A., Raeburn, D. Br. J. Pharmacol. (1996) [Pubmed]
  23. Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism. Yasui, K., Agematsu, K., Shinozaki, K., Hokibara, S., Nagumo, H., Nakazawa, T., Komiyama, A. J. Leukoc. Biol. (2000) [Pubmed]
  24. Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Grant, M.B., Davis, M.I., Caballero, S., Feoktistov, I., Biaggioni, I., Belardinelli, L. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  25. Enprofylline and theophylline slow-eroding tablets in the treatment of asthma: a comparison. Laursen, L.C., Eriksson, G., Weeke, B. Respiration; international review of thoracic diseases. (1986) [Pubmed]
  26. Effect of aminophylline and enprofylline on the protective efficacy of common antiepileptic drugs against electroconvulsions in mice. Czuczwar, S.J., Kleinrok, Z., Turski, L., Turski, W.A. Epilepsia (1987) [Pubmed]
  27. Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. Finney, M.J., Karlsson, J.A., Persson, C.G. Br. J. Pharmacol. (1985) [Pubmed]
  28. Inhibition of pyridoxal kinase by methylxanthines. Ubbink, J.B., Bissbort, S., Vermaak, W.J., Delport, R. Enzyme (1990) [Pubmed]
  29. Intravenous infusion of enprofylline with an exponentially decreasing drug concentration in acute asthma. Arnman, K., Willén, B., Borgström, L., Conradson, T.B. Therapeutic drug monitoring. (1989) [Pubmed]
  30. Dose-dependent pharmacokinetics of enprofylline and its renal handling in rats. Nadai, M., Hasegawa, T., Muraoka, I., Takagi, K., Nabeshima, T. Journal of pharmaceutical sciences. (1991) [Pubmed]
  31. Alterations in the pharmacokinetics and protein binding of enprofylline in Eisai hyperbilirubinemic rats. Nadai, M., Hasegawa, T., Wang, L., Tagaya, O., Nabeshima, T. Drug Metab. Dispos. (1994) [Pubmed]
  32. Enprofylline: pharmacokinetics and comparison with theophylline of acute effects on bronchial reactivity in normal subjects. Kluge, T.B., Oellerich, M., Schumann, G., Sybrecht, G.W. Eur. J. Clin. Pharmacol. (1986) [Pubmed]
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