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Chemical Compound Review:

CHEMBL909 8-chloro-10-(3- dimethylaminopropyl)phenoth...

Synonyms: SureCN2389266, CCG-37119, NSC-131053, NCI131053, NSC131053, ...

Phillipson, O.T. et al., Chetty, M. et al., Yeung, P.K. et al., Bronaugh, R.L. et al., Neptune, M. et al., et al.

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Psychiatry related information on 7-Hydroxy-2-chloro-10-[3'-(dimethylamino)-N-propyl]phenothiazine

These showed that the most significant correlations occurred when symptoms with high diagnostic significance for schizophrenia (Group 1) and symptoms rating perceptual disorders (P) were correlated with plasma 7OHCPZ levels in plasma samples taken before the first morning dose of CPZ [1].

High impact information on 7-Hydroxy-2-chloro-10-[3'-(dimethylamino)-N-propyl]phenothiazine

The oxidation of 7-hydroxychlorpromazine, a process associated with several side effects of chlorpromazine therapy, was examined in vitro by electrochemistry and rapid-scanning spectrophotometry [2].
7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients [3].
Fifteen schizophrenic patients were included in this study and regression analysis was used to determine any correlation between CPZ, 7-hydroxychlorpromazine, Chlorpromazine-N-oxide, Nor1 chlorpromazine, Nor2 chlorpromazine, chlorpromazine sulfoxide, Nor2 chlorpromazine sulfoxide and blood pressure, pulse rate, sedation and finger tremor [4].
It was used together with the previously developed RIAs for CPZ, chlorpromazine sulfoxide (CPZSO), and 7-hydroxychlorpromazine (7-OHCPZ) to study the pharmacokinetics of CPZ and these metabolites in five healthy volunteers after they received a single 50-mg oral dose of CPZ [5].
Chlorpromazine, nor1-chlorpromazine and 7-hydroxychlorpromazine reverse the apomorphine-elicited inhibition of tyrosine hydroxylase activity while nor1-chlorpromazine sulfoxide and nor2-chlorpromazine sulfoxide have no effect on this inhibition [6].

Analytical, diagnostic and therapeutic context of 7-Hydroxy-2-chloro-10-[3'-(dimethylamino)-N-propyl]phenothiazine

A comparison of two radioimmunoassays for 7-hydroxychlorpromazine: rabbit polyclonal antibodies vs. mouse monoclonal antibodies [7].

References

Correlation between plasma chlorpromazine and its metabolites and clinical ratings in patients with acute relapse of schizophrenic and paranoid psychosis. Phillipson, O.T., McKeown, J.M., Baker, J., Healey, A.F. The British journal of psychiatry : the journal of mental science. (1977) [Pubmed]
Chemical and electrochemical oxidation of 7-hydroxychlorpromazine. Neptune, M., McCreery, R.L. J. Med. Chem. (1978) [Pubmed]
The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients. Alfredsson, G., Lindberg, M., Sedvall, G. Psychopharmacology (Berl.) (1982) [Pubmed]
The use of a side effect as a qualitative indicator of plasma chlorpromazine levels. Chetty, M., Gouws, E., Miller, R., Moodley, S.V. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1999) [Pubmed]
Radioimmunoassay for the N-oxide metabolite of chlorpromazine in human plasma and its application to a pharmacokinetic study in healthy humans. Yeung, P.K., Hubbard, J.W., Korchinski, E.D., Midha, K.K. Journal of pharmaceutical sciences. (1987) [Pubmed]
The effect of various chlorpromazine derivatives on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Bronaugh, R.L., Goldstein, M. Psychopharmacology communications. (1975) [Pubmed]
A comparison of two radioimmunoassays for 7-hydroxychlorpromazine: rabbit polyclonal antibodies vs. mouse monoclonal antibodies. Yeung, P.K., McKay, G., Ramshaw, I.A., Hubbard, J.W., Midha, K.K. J. Pharmacol. Exp. Ther. (1985) [Pubmed]

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