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Chemical Compound Review

CHEMBL909     8-chloro-10-(3- dimethylaminopropyl)phenoth...

Synonyms: SureCN2389266, CCG-37119, NSC-131053, NCI131053, NSC131053, ...
 
 
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Psychiatry related information on 7-Hydroxy-2-chloro-10-[3'-(dimethylamino)-N-propyl]phenothiazine

  • These showed that the most significant correlations occurred when symptoms with high diagnostic significance for schizophrenia (Group 1) and symptoms rating perceptual disorders (P) were correlated with plasma 7OHCPZ levels in plasma samples taken before the first morning dose of CPZ [1].
 

High impact information on 7-Hydroxy-2-chloro-10-[3'-(dimethylamino)-N-propyl]phenothiazine

 

Analytical, diagnostic and therapeutic context of 7-Hydroxy-2-chloro-10-[3'-(dimethylamino)-N-propyl]phenothiazine

References

  1. Correlation between plasma chlorpromazine and its metabolites and clinical ratings in patients with acute relapse of schizophrenic and paranoid psychosis. Phillipson, O.T., McKeown, J.M., Baker, J., Healey, A.F. The British journal of psychiatry : the journal of mental science. (1977) [Pubmed]
  2. Chemical and electrochemical oxidation of 7-hydroxychlorpromazine. Neptune, M., McCreery, R.L. J. Med. Chem. (1978) [Pubmed]
  3. The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients. Alfredsson, G., Lindberg, M., Sedvall, G. Psychopharmacology (Berl.) (1982) [Pubmed]
  4. The use of a side effect as a qualitative indicator of plasma chlorpromazine levels. Chetty, M., Gouws, E., Miller, R., Moodley, S.V. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1999) [Pubmed]
  5. Radioimmunoassay for the N-oxide metabolite of chlorpromazine in human plasma and its application to a pharmacokinetic study in healthy humans. Yeung, P.K., Hubbard, J.W., Korchinski, E.D., Midha, K.K. Journal of pharmaceutical sciences. (1987) [Pubmed]
  6. The effect of various chlorpromazine derivatives on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Bronaugh, R.L., Goldstein, M. Psychopharmacology communications. (1975) [Pubmed]
  7. A comparison of two radioimmunoassays for 7-hydroxychlorpromazine: rabbit polyclonal antibodies vs. mouse monoclonal antibodies. Yeung, P.K., McKay, G., Ramshaw, I.A., Hubbard, J.W., Midha, K.K. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
 
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