Disease relevance of Perceptual Disorders

• Injection of a low dose of haloperidol, that has no obvious behavioral effects in normal mice, produces akinesia, catalepsy, and sensory neglect in MPTP-treated mice [1].

Psychiatry related information on Perceptual Disorders

• Patients with left hemispatial neglect resulting from right hemisphere damage performed a vibrotactile reaction time (RT) task with the stimulated and responding (right) limb placed either ipsilaterally in right hemispace, or across the midline in contralateral (left) hemispace [2].

High impact information on Perceptual Disorders

• Bizarre perceptual disorder of extremities in patients taking verapamil [3].
• CONCLUSIONS: Damage in the parietal and anterior cingulate cortex and posterior white matter fiber bundles correlated with hemispatial neglect [4].
• These showed that the most significant correlations occurred when symptoms with high diagnostic significance for schizophrenia (Group 1) and symptoms rating perceptual disorders (P) were correlated with plasma 7OHCPZ levels in plasma samples taken before the first morning dose of CPZ [5].
• Neonatal rEpo treatment protected dopamine neurons as indicated by the preservation of tyrosine hydroxylase-positive cells in the substantia nigra pars compacta and ventral tegmental area. rEpo treatment also improved functional outcomes by reducing sensory neglect and preventing the rotational asymmetry seen in control animals [6].
• Sensory neglect and apomorphine-induced rotation were measured at P27 and P28 [6].

Chemical compound and disease context of Perceptual Disorders

• Moreover, it has been proposed that this increase in inhibitory activity within the colliculus may be responsible for the sensory neglect commonly observed after dopamine denervation [7].
• With regard to behavioral outcome, only 5 days of progesterone injections resulted in improved spatial learning performance and reduced sensory neglect [8].
• In rats demonstrating sensory neglect, d-amphetamine or apomorphine induction of Fos in the ipsilateral CPu was reduced by about 40% compared to the contralateral CPu or to comparable readings in unlesioned controls [9].
• These results replicate previous findings that right hemisphere inactivation during the intracarotid sodium amobarbital test results in left hemispatial neglect [10].
• Thus, there is a clear relation between the degree of hemispheric inactivation induced by the amobarbital and the degree of left hemispatial neglect [10].

Anatomical context of Perceptual Disorders

• Time-dependent changes in dopamine agonist-induced striatal Fos immunoreactivity are related to sensory neglect and its recovery after unilateral prefrontal cortex injury [9].

Gene context of Perceptual Disorders

• The Character-line Bisection Task: a new test for hemispatial neglect [11].
• [Harvey M, Milner AD, Roberts RC. An investigation of hemispatial neglect using the landmark task, Brain and Cognition 1995; 27: 59-78] has shown that in neglect patients cues work by inducing orientational biases rather than via the alteration of subjective length perception [12].
• Further classes of PSE symptoms as perceptual disorder, thought disorder, and delusions of influence predicted poor outcome too [13].
• Thirteen patients with hemispatial neglect were tested both with the Landmark Test, adapted from Milner et al [14].

References