Disease relevance of EINECS 254-430-0

• Her history was remarkable for duodenal ulcer and long-term treatment with a magnesium-aluminum hydroxide antacid (Maalox) and sucralfate [1].
• Neither magnesium-aluminum hydroxide (36.3 g/24 hr, P = 0.22), nor calcium carbonate (39.0 g/24 hr, P = 0.029), improved efficacy of enzyme therapy and, in fact, tended to enhance steatorrhea [2].

High impact information on EINECS 254-430-0

• Specifically, we examined the effect of dermal pretreatment with 0.5% hydrocortisone cream and with an over-the-counter antacid, magnesium-aluminum hydroxide suspension, on the pharmacokinetics of transdermal clonidine in 10 adult hypertensive males [3].
• Supine and sitting blood pressures and pulse rates were similar during treatment with clonidine alone, following dermal pretreatment with hydrocortisone cream, and following pretreatment with magnesium-aluminum hydroxide suspension [3].
• Magnesium-aluminum hydroxide gel reduced bioavailability by 90% [4].
• Ten healthy volunteers ingested single 15-mg doses of clorazepate dipotassium (CZP) with 60 ml of water, or with 60 ml of magnesium aluminum hydroxide (Maalox), on two occasions in a randomized, two-way crossover study [5].
• The mean area under the curve (AUC) was significantly decreased by AMH (p less than 0.005) and CC (p less than 0.05) [6].

Anatomical context of EINECS 254-430-0

• The effect of sodium bicarbonate versus aluminum-magnesium hydroxide on postprandial gastric acid in duodenal ulcer patients [7].

Associations of EINECS 254-430-0 with other chemical compounds

• Gastric administration of cimetidine, 5 mg/kg, and magnesium aluminum hydroxide gel (Maalox), 1 ml/kg, were equally effective raising the gastric pH of mice from 2.5 to 5 [8].

References