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Chemical Compound Review

Tranxene     dipotassium10-chloro-5-oxo-2- phenyl-3,6...

Synonyms: Belseren, Tencilan, Nevracten, Tranxilen, Mendon, ...
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Disease relevance of Chlorazepate


Psychiatry related information on Chlorazepate


High impact information on Chlorazepate


Chemical compound and disease context of Chlorazepate


Biological context of Chlorazepate


Anatomical context of Chlorazepate


Associations of Chlorazepate with other chemical compounds


Gene context of Chlorazepate

  • The association constants and the enthalpy variations are equal to 14 000 +/- 2000 M-1 and --6.6 +/- 0.2 kcal/mol for human serum albumin . tryptophan complex and 13 000 +/- 1000 M-1 and --10.0 +/- 0.2 kcal/mol for human serum albumin . chlorazepate complex [16].

Analytical, diagnostic and therapeutic context of Chlorazepate


  1. Delayed maze-learning in rats after prenatal exposure to clorazepate. Pascuzzi Jackson, V., DeMyer, W., Hingtgen, J. Arch. Neurol. (1980) [Pubmed]
  2. In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: drug-specific proliferation associated with interleukin-5 secretion. Sachs, B., Erdmann, S., Al-Masaoudi, T., Merk, H.F. Br. J. Dermatol. (2001) [Pubmed]
  3. Hypersensitivity to chlorazepate dipotassium. Aznar, R.C., Calatayud, M.D., Martín, M.A., López, D.E., Hernández, A.P. Allergy (2005) [Pubmed]
  4. Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats. Amano, K., Takamatsu, J., Ogata, A., Katsuragi, S., Miyazaki, C., Deshimaru, M., Sumiyoshi, S., Miyakawa, T. Eur. J. Pharmacol. (1999) [Pubmed]
  5. The effects of repeated nocturnal doses of clobazam, dipotassium chlorazepate and placebo on subjective ratings of sleep and early morning behaviour and objective measures of arousal, psychomotor performance and anxiety. Hindmarch, I., Parrott, A.C. British journal of clinical pharmacology. (1979) [Pubmed]
  6. Clorazepate dipotassium versus midazolam for premedication in clear corneal cataract surgery. Laube, T., Krohner, H., Franke, G.H., Brockmann, C., Steuhl, K.P. Journal of cataract and refractive surgery. (2003) [Pubmed]
  7. Benzodiazepines in panic disorder and agoraphobia. Sheehan, D.V. Journal of affective disorders. (1987) [Pubmed]
  8. Effects of clorazepate dipotassium and placebo on psychomotor skills. Moodley, P., Golombok, S., Lader, M. Perceptual and motor skills. (1985) [Pubmed]
  9. Chlorazepate in temporal lobe epilepsy. Feldman, R.G. JAMA (1976) [Pubmed]
  10. Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. Gebhardt, A.C., Lucas, D., Ménez, J.F., Seitz, H.K. Hepatology (1997) [Pubmed]
  11. Failure of clorazepate to cause malformations or fetal wastage in the rat. Corwin, H., DeMyer, W. Arch. Neurol. (1980) [Pubmed]
  12. Pharmacokinetics of chlorazepate after intravenous and intramuscular administration. Bertler, A., Lindgren, S., Magnusson, J.O., Malmgren, H. Psychopharmacology (Berl.) (1983) [Pubmed]
  13. Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate. Post, C., Lindgren, S., Bertler, A., Malmgren, H. Psychopharmacology (Berl.) (1977) [Pubmed]
  14. Clinical and experimental comparison of diazepam, chlorazepate and placebo. Dureman, I., Norrman, B. Psychopharmacologia. (1975) [Pubmed]
  15. Steady-state bioavailability of two clorazepate dipotassium dosage forms. Carrigan, P.J., Chao, G.C., Barker, W.M., Hoffman, D.J., Chun, A.H. Journal of clinical pharmacology. (1977) [Pubmed]
  16. Microcalorimetric method to determine competitive binding. Action of a psychotropic drug (dipotassium chlorazepate) on L-tryptophan . human serum albumin complex. Coassolo, P., Briand, C., Bourdeaux, M., Sari, J.C. Biochim. Biophys. Acta (1978) [Pubmed]
  17. Stability of the powdered dosage form prepared by unsealing the capsules: water vapor sorption and discoloration of the powdery contents of clorazepate dipotassium capsules. Hanawa, T., Ohta, T., Kimura, F., Tsuchiya, T., Ikoma, R., Uchida, T., Suzuki, M., Nakajima, S. Drug development and industrial pharmacy. (2000) [Pubmed]
  18. Blisters of the skin in coma induced by amitriptyline and clorazepate dipotassium. Report of a case with underlying sweat gland necrosis. Herschthal, D., Robinson, M.J. Archives of dermatology. (1979) [Pubmed]
  19. Behavioural and pharmacokinetic studies in the monkey (Macaca mulatta) with diazepam, nordiazepam and related 1,4-benzodiazepines. Curry, S.H., Whelpton, R., Nicholson, A.N., Wright, C.M. Br. J. Pharmacol. (1977) [Pubmed]
  20. The effects of anesthesia with increasing end-expiratory concentrations of sevoflurane on midlatency auditory evoked potentials. Schwender, D., Conzen, P., Klasing, S., Finsterer, U., Pöppel, E., Peter, K. Anesth. Analg. (1995) [Pubmed]
  21. Intramuscular bioavailability of chlorazepate as compared to diazepam. Bertler, A., Lindgren, S., Magnusson, J.O., Malmgren, H. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
  22. Pharmacological and clinical effects of buspirone. Taylor, D.P., Eison, M.S., Riblet, L.A., Vandermaelen, C.P. Pharmacol. Biochem. Behav. (1985) [Pubmed]
  23. Chlorazepate for premedication. Jeal, D.E. British journal of anaesthesia. (1979) [Pubmed]
  24. Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam. Greenblatt, D.J., Divoll, M.K., Soong, M.H., Boxenbaum, H.G., Harmatz, J.S., Shader, R.I. Journal of clinical pharmacology. (1988) [Pubmed]
  25. A brief anxiety rating scale in evaluating anxiolytics. Wang, R.I., Wiesen, R.L., Treul, S., Stockdale, S. Journal of clinical pharmacology. (1976) [Pubmed]
  26. Clorazepate dipotassium and diazepam in renal insufficiency: serum concentrations and protein binding of diazepam and desmethyldiazepam. Ochs, H.R., Rauh, H.W., Greenblatt, D.J., Kaschell, H.J. Nephron (1984) [Pubmed]
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