Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-K-89014 (4-carbamimidoylphenyl) methanesulfonyl...

Synonyms: KST-1A8040, AC1Q6YNS, CTK5D5266, AR-1A5644, KB-207827, ...

Tatakis, D.N. et al., Nagano, A. et al., Yamaguchi, T. et al.

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Disease relevance of p-Apmsf

Either hirudin or (4-amidinophenyl)methanesulfonyl fluoride inhibited, in a dose-dependent manner, the effects of thrombin on human osteoblast-like osteosarcoma cells (G292 and Saos-2 cell lines) and on normal rat calvarial osteoblastic cells [1].

High impact information on p-Apmsf

Contraction was completely blocked by 1 mM (p-amidinophenyl)methanesulfonyl fluoride, a serine protease inhibitor [2].
On the other hand, we observed that protease inhibitors (such as TLCK, TPCK, PMSF, p-APMSF, Pefabloc SC and Z-Asp-CH2-DCB) blocked intracellular acidification, DNA fragmentation and FUdR-induced cell death [3].

References

Thrombin effects on osteoblastic cells. II. Structure-function relationships. Tatakis, D.N., Dolce, C., Dziak, R., Fenton, J.W. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
A potent vasoconstrictor in the rat submandibular gland. Yamaguchi, T., Carretero, O.A., Scicli, A.G. Hypertension (1991) [Pubmed]
The molecular mechanisms of 5-fluoro-2'-deoxyuridine induced cell death. Nagano, A., Kakutani, T., Matumoto, Y., Ebara, Y., Kanja, K., Kankawa, S., Wataya, Y. Nucleic Acids Symp. Ser. (1997) [Pubmed]

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