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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AC1L5ATY     (2S)-N-[(1S)-1-[[(2S)-5...

Synonyms: Pro-phe-arg-mca, Factor Xa Fluorogenic Substrate
 
 
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High impact information on Pro-phe-arg-mca

 

Biological context of Pro-phe-arg-mca

  • 2. Furthermore, in order to define whether brain kallikrein levels vary in the aging process, the hydrolyzing activity in the cerebrum L-prolyl-L-phenylalanyl-L-arginine-4-methyl-coumaryl-7-amide (Pro-Phe-Arg-MCA) was measured in young (7-week old) and old (36-week old) female senescence accelerated mice (SAM-P/8 and SAM-R/1) [5].
 

Analytical, diagnostic and therapeutic context of Pro-phe-arg-mca

  • From rat stomach, kallikrein was purified by chromatographies on columns of p-aminobenzamidine-Sepharose, DEAE-Sephadex A-50 and Sephadex G-150 and by isoelectric focusing, measuring its activities to hydrolyse prolylphenylalanyl-arginine-4-methyl-coumarine amide (Pro-Phe-Arg-MCA) and to release kinin from rat heated-plasma [6].

References

  1. Potential role of kallikrein in diurnal rhythms and perivascular distribution in rat pineal glands. Kudo, M., Yamazaki, I., Suzuki, T., Ebihara, Y., Iwadate, H., Kizuki, K. Brain Res. (1998) [Pubmed]
  2. Endopeptidase activity of cathepsin C, dipeptidyl aminopeptidase I, from bovine spleen. Kuribayashi, M., Yamada, H., Ohmori, T., Yanai, M., Imoto, T. J. Biochem. (1993) [Pubmed]
  3. Purification and characterization of two arginine ester hydrolases from Vipera berus berus (common viper) venom. Samel, M., Siigur, E., Siigur, J. Toxicon (1987) [Pubmed]
  4. A new fluorogenic substrate method for the estimation of kallikrein in urine. Kato, H., Adachi, N., Iwanaga, S., Abe, K., Takada, K., Kimura, T., Sakakibara, S. J. Biochem. (1980) [Pubmed]
  5. Tissue kallikrein in rat and mouse neurons. Kizuki, K., Suzuki, T., Sugaya, K., Noguchi, T., Kudo, M. Braz. J. Med. Biol. Res. (1994) [Pubmed]
  6. Rat stomach kallikrein: its purification and properties. Uchida, K., Yokoshima, A., Niinobe, M., Kato, H., Fujii, S. Adv. Exp. Med. Biol. (1979) [Pubmed]
 
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