The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1L5ATY     (2S)-N-[(1S)-1-[[(2S)-5...

Synonyms: Pro-phe-arg-mca, Factor Xa Fluorogenic Substrate
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pro-phe-arg-mca


Biological context of Pro-phe-arg-mca

  • 2. Furthermore, in order to define whether brain kallikrein levels vary in the aging process, the hydrolyzing activity in the cerebrum L-prolyl-L-phenylalanyl-L-arginine-4-methyl-coumaryl-7-amide (Pro-Phe-Arg-MCA) was measured in young (7-week old) and old (36-week old) female senescence accelerated mice (SAM-P/8 and SAM-R/1) [5].

Analytical, diagnostic and therapeutic context of Pro-phe-arg-mca

  • From rat stomach, kallikrein was purified by chromatographies on columns of p-aminobenzamidine-Sepharose, DEAE-Sephadex A-50 and Sephadex G-150 and by isoelectric focusing, measuring its activities to hydrolyse prolylphenylalanyl-arginine-4-methyl-coumarine amide (Pro-Phe-Arg-MCA) and to release kinin from rat heated-plasma [6].


  1. Potential role of kallikrein in diurnal rhythms and perivascular distribution in rat pineal glands. Kudo, M., Yamazaki, I., Suzuki, T., Ebihara, Y., Iwadate, H., Kizuki, K. Brain Res. (1998) [Pubmed]
  2. Endopeptidase activity of cathepsin C, dipeptidyl aminopeptidase I, from bovine spleen. Kuribayashi, M., Yamada, H., Ohmori, T., Yanai, M., Imoto, T. J. Biochem. (1993) [Pubmed]
  3. Purification and characterization of two arginine ester hydrolases from Vipera berus berus (common viper) venom. Samel, M., Siigur, E., Siigur, J. Toxicon (1987) [Pubmed]
  4. A new fluorogenic substrate method for the estimation of kallikrein in urine. Kato, H., Adachi, N., Iwanaga, S., Abe, K., Takada, K., Kimura, T., Sakakibara, S. J. Biochem. (1980) [Pubmed]
  5. Tissue kallikrein in rat and mouse neurons. Kizuki, K., Suzuki, T., Sugaya, K., Noguchi, T., Kudo, M. Braz. J. Med. Biol. Res. (1994) [Pubmed]
  6. Rat stomach kallikrein: its purification and properties. Uchida, K., Yokoshima, A., Niinobe, M., Kato, H., Fujii, S. Adv. Exp. Med. Biol. (1979) [Pubmed]
WikiGenes - Universities