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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

CHEMBL7550     8-ethyl-3,5-dimethyl-9-[[4- [2-(2H-tetrazol...

Synonyms: SureCN683357, SureCN5344127, CHEBI:102725, DNC011714, LS-193980, ...
 
 
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Disease relevance of L158809

  • In addition, L158809 did not alter the pressor response to hypoxia, whereas responses to angiotensin II were reduced in a selective manner.(ABSTRACT TRUNCATED AT 250 WORDS)[1]
 

High impact information on L158809

  • Two months later, they were treated for two months with: 1) vehicle; 2) AT(1)-ant (L158809, Merck, Rahway, New Jersey); 3) AT(1)-ant + AT(2)-ant (PD-123319, Parke Davis, Ann Arbor, Michigan); or 4) AT(1)-ant + kinin B(2) receptor antagonist (B(2)-ant) (icatibant) (only BN) [2].
  • The 0.01-0.1 nM AII-VC unmasked by the potentiating effect of NO inhibition, were sensitive not only to AT1 (L158809), but also to AT2 receptor (PD123319) antagonists [3].
  • 4. In the presence of L-NAME, 500 nM L158809 abolished the Ang II-induced vasoconstrictions whatever the concentration tested [4].
  • The effect of the octapeptide on both frequency and amplitude of the nuclear waves was prevented by the AT1 receptor antagonist L158809 [5].

References

  1. Influence of N omega-nitro-L-arginine methyl ester, LY83583, glybenclamide and L158809 on pulmonary circulation. Feng, C.J., Cheng, D.Y., Kaye, A.D., Kadowitz, P.J., Nossaman, B.D. Eur. J. Pharmacol. (1994) [Pubmed]
  2. Role of angiotensin II type 2 receptors and kinins in the cardioprotective effect of angiotensin II type 1 receptor antagonists in rats with heart failure. Liu, Y.H., Yang, X.P., Shesely, E.G., Sankey, S.S., Carretero, O.A. J. Am. Coll. Cardiol. (2004) [Pubmed]
  3. AT2 antagonist-sensitive potentiation of angiotensin II-induced constriction by NO blockade and its dependence on endothelium and P450 eicosanoids in rat renal vasculature. Muller, C., Endlich, K., Helwig, J.J. Br. J. Pharmacol. (1998) [Pubmed]
  4. AT2-antagonist sensitive potentiation of angiotensin II-induced vasoconstrictions by blockade of nitric oxide synthesis in rat renal vasculature. Muller, C., Endlich, K., Barthelmebs, M., Helwig, J.J. Br. J. Pharmacol. (1997) [Pubmed]
  5. Angiotensin II induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors. Bkaily, G., El-Bizri, N., Nader, M., Hazzouri, K.M., Riopel, J., Jacques, D., Regoli, D., D'Orleans-Juste, P., Gobeil, F., Avedanian, L. Peptides (2005) [Pubmed]
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