The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Agtr2  -  angiotensin II receptor, type 2

Rattus norvegicus

Synonyms: AT2, AT2-R, AT2R, Angiotensin II type-2 receptor, Type-2 angiotensin II receptor
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Agtr2


Psychiatry related information on Agtr2


High impact information on Agtr2

  • The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats [8].
  • Here we report that ANG II via its ANG II type 2 (AT2) receptor promotes the axonal elongation of postnatal rat retinal explants (postnatal day 11) and dorsal root ganglia neurons in vitro, and, moreover, axonal regeneration of retinal ganglion cells after optic nerve crush in vivo [8].
  • Among the effector peptides of the brain RAS, angiotensin II and angiotensin III have the same affinity for the two pharmacologically well-defined receptors: type 1 (AT1) and type 2 (AT2) [9].
  • L-arginine (L-ARG) given intravenously or interstitially enhanced net fluid absorption and cGMP formation, which were completely blocked by the nitric oxide (NO) synthase inhibitor, N-nitro-L-arginine methylester (L-NAME), but not by the specific AT2 receptor antagonist, PD-123319 (PD) [10].
  • We examined potential mechanisms by which angiotensin subtype-2 (AT2) receptor stimulation induces net fluid absorption and serosal guanosine cyclic 3',5'-monophosphate (cGMP) formation in the rat jejunum [10].

Chemical compound and disease context of Agtr2


Biological context of Agtr2


Anatomical context of Agtr2


Associations of Agtr2 with chemical compounds


Physical interactions of Agtr2


Co-localisations of Agtr2


Regulatory relationships of Agtr2


Other interactions of Agtr2


Analytical, diagnostic and therapeutic context of Agtr2


  1. Regulation of vascular proteoglycan synthesis by angiotensin II type 1 and type 2 receptors. Shimizu-Hirota, R., Sasamura, H., Mifune, M., Nakaya, H., Kuroda, M., Hayashi, M., Saruta, T. J. Am. Soc. Nephrol. (2001) [Pubmed]
  2. Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Touyz, R.M., Endemann, D., He, G., Li, J.S., Schiffrin, E.L. Hypertension (1999) [Pubmed]
  3. Early streptozotocin-diabetes mellitus downregulates rat kidney AT2 receptors. Wehbi, G.J., Zimpelmann, J., Carey, R.M., Levine, D.Z., Burns, K.D. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  4. Angiotensin II protects cultured midbrain dopaminergic neurons against rotenone-induced cell death. Grammatopoulos, T.N., Ahmadi, F., Jones, S.M., Fariss, M.W., Weyhenmeyer, J.A., Zawada, W.M. Brain Res. (2005) [Pubmed]
  5. Transient upregulation of the AT2 receptor mRNA level after global ischemia in the rat brain. Makino, I., Shibata, K., Ohgami, Y., Fujiwara, M., Furukawa, T. Neuropeptides (1996) [Pubmed]
  6. Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary. Sanvitto, G.L., Jöhren, O., Häuser, W., Saavedra, J.M. Am. J. Physiol. (1997) [Pubmed]
  7. Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain. Tsutsumi, K., Saavedra, J.M. Am. J. Physiol. (1991) [Pubmed]
  8. The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats. Lucius, R., Gallinat, S., Rosenstiel, P., Herdegen, T., Sievers, J., Unger, T. J. Exp. Med. (1998) [Pubmed]
  9. Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review. Lenkei, Z., Palkovits, M., Corvol, P., Llorens-Cortès, C. Frontiers in neuroendocrinology. (1997) [Pubmed]
  10. Compartmentalization of extracellular cGMP determines absorptive or secretory responses in the rat jejunum. Jin, X.H., Siragy, H.M., Guerrant, R.L., Carey, R.M. J. Clin. Invest. (1999) [Pubmed]
  11. Angiotensin AT1 receptors in the preoptic area negatively modulate the cardiovascular and ACTH responses induced in rats by intrapreoptic injection of prostaglandin E2. Watanabe, T., Sakata, Y., Wada, M. Brain Res. (2000) [Pubmed]
  12. Cardiac angiotensin II receptor populations during aortocaval fistulae, AII and beta adrenergic receptor blockade. Poole, T.D., Holder, M.S., Gipson, D. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  13. AT1 receptors mediate pressor responses induced by angiotensin II in the periaqueductal gray area of rats. D'Amico, M., Di Filippo, C., Berrino, L., Rossi, F. Life Sci. (1997) [Pubmed]
  14. Increased AT(2)R protein expression but not increased apoptosis during cardioprotection induced by AT(1)R blockade. Moudgil, R., Musat-Marcu, S., Xu, Y., Kumar, D., Jugdutt, B.I. The Canadian journal of cardiology. (2002) [Pubmed]
  15. Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats. Hsieh, P.S., Tai, Y.H., Loh, C.H., Shih, K.C., Cheng, W.T., Chu, C.H. Metab. Clin. Exp. (2005) [Pubmed]
  16. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. Mukoyama, M., Nakajima, M., Horiuchi, M., Sasamura, H., Pratt, R.E., Dzau, V.J. J. Biol. Chem. (1993) [Pubmed]
  17. Growth-dependent induction of angiotensin II type 2 receptor in rat mesangial cells. Goto, M., Mukoyama, M., Suga, S., Matsumoto, T., Nakagawa, M., Ishibashi, R., Kasahara, M., Sugawara, A., Tanaka, I., Nakao, K. Hypertension (1997) [Pubmed]
  18. Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor. Pucell, A.G., Hodges, J.C., Sen, I., Bumpus, F.M., Husain, A. Endocrinology (1991) [Pubmed]
  19. Molecular mechanism of angiotensin II type I and type II receptors in cardiac hypertrophy of spontaneously hypertensive rats. Makino, N., Sugano, M., Otsuka, S., Hata, T. Hypertension (1997) [Pubmed]
  20. Pivotal role of tyrosine phosphatase SHP-1 in AT2 receptor-mediated apoptosis in rat fetal vascular smooth muscle cell. Cui, T., Nakagami, H., Iwai, M., Takeda, Y., Shiuchi, T., Daviet, L., Nahmias, C., Horiuchi, M. Cardiovasc. Res. (2001) [Pubmed]
  21. Localization of the genes encoding the three rat angiotensin II receptors, Agtr1a, Agtr1b, Agtr2, and the human AGTR2 receptor respectively to rat chromosomes 17q12, 2q24 and Xq34, and the human Xq22. Tissir, F., Rivière, M., Guo, D.F., Tsuzuki, S., Inagami, T., Levan, G., Szpirer, J., Szpirer, C. Cytogenet. Cell Genet. (1995) [Pubmed]
  22. Angiotensin II-induced nuclear targeting of the angiotensin type 1 (AT1) receptor in brain neurons. Lu, D., Yang, H., Shaw, G., Raizada, M.K. Endocrinology (1998) [Pubmed]
  23. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Hakam, A.C., Hussain, T. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  24. Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition. Miura, S., Karnik, S.S. J. Hypertens. (1999) [Pubmed]
  25. Immunohistochemical colocalization of type II angiotensin receptors with somatostatin in rat pancreas. Wong, P.F., Lee, S.S., Cheung, W.T. Regul. Pept. (2004) [Pubmed]
  26. A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding. Saavedra, J.M., Armando, I., Bregonzio, C., Juorio, A., Macova, M., Pavel, J., Sanchez-Lemus, E. Neuropsychopharmacology (2006) [Pubmed]
  27. Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation. Siragy, H.M., Xue, C., Abadir, P., Carey, R.M. Hypertension (2005) [Pubmed]
  28. Effect of AT2 receptor on expression of AT1 and TGF-beta receptors in VSMCs from SHR. Su, J.Z., Fukuda, N., Jin, X.Q., Lai, Y.M., Suzuki, R., Tahira, Y., Takagi, H., Ikeda, Y., Kanmatsuse, K., Miyazaki, H. Hypertension (2002) [Pubmed]
  29. Angiotensin II activates the Na+/HCO3- symport through a phosphoinositide-independent mechanism in cardiac cells. Kohout, T.A., Rogers, T.B. J. Biol. Chem. (1995) [Pubmed]
  30. Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells. Zhao, Y., Biermann, T., Luther, C., Unger, T., Culman, J., Gohlke, P. J. Neurochem. (2003) [Pubmed]
  31. Characterization of the angiotensin II AT1 receptor subtype involved in DNA synthesis in cultured vascular smooth muscle cells. Briand, V., Riva, L., Galzin, A.M. Br. J. Pharmacol. (1994) [Pubmed]
  32. Angiotensin II type-2 (AT2) receptor-mediated inhibition of NMDA receptor signalling in neuronal cells. Schelman, W.R., Kurth, J.L., Berdeaux, R.L., Norby, S.W., Weyhenmeyer, J.A. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  33. Angiotensin II induces hypoxia-inducible factor-1 alpha in PC 12 cells through a posttranscriptional mechanism: role of AT2 receptors. Wolf, G., Schroeder, R., Stahl, R.A. American journal of nephrology. (2004) [Pubmed]
  34. Angiotensin receptor subtypes in thin and muscular juxtamedullary efferent arterioles of rat kidney. Helou, C.M., Imbert-Teboul, M., Doucet, A., Rajerison, R., Chollet, C., Alhenc-Gelas, F., Marchetti, J. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  35. The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy. D'Amore, A., Black, M.J., Thomas, W.G. Hypertension (2005) [Pubmed]
  36. Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet. Ruan, X., Wagner, C., Chatziantoniou, C., Kurtz, A., Arendshorst, W.J. J. Clin. Invest. (1997) [Pubmed]
WikiGenes - Universities