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Chemical Compound Review:

OLAN (3S,10S,13R,14R,17R)-17- [(2R)-4-(3,3...

Synonyms: KST-1A2688, AC1L4NYK, AR-1A5052, 18303-41-8, 24,25-Epoxylanosterol, ...

Taylor, F.R. et al., Gardner, R.G. et al., Emmons, G.T. et al., Panini, S.R. et al., Behr, P. et al.

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High impact information on 24,25-Oxidolanosterol

Genetic manipulation of oxidosqualene-lanosterol cyclase did result in the buildup of detectable levels of 24,25-oxidolanosterol by gas chromatography, gas chromatography-mass spectroscopy, and NMR analyses, whereas no detectable amounts were observed in wild-type cells or cells with squalene epoxidase down-regulated [1].
Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 24(S),25-oxidolanosterol [2].
In view of the potential importance of 24,25-epoxysterols as intracellular regulators of 3-hydroxy-3-methylglutaryl-CoA reductase, the C-24 epimers of 24,25-oxidolanosterol and 24,25-epoxycholesterol were tested for their biological activity and metabolism in cell cultures [3].
24(S),25-Oxidolanosterol was rapidly converted to 24(S),25-epoxycholesterol in both cell lines [3].
The 24R and 24S epimers of the acetates of 24,25-epoxycholesterol and 24,25-epoxylanosterol have been prepared and purified by preparative normal phase high performance liquid chromatography [4].

Associations of 24,25-Oxidolanosterol with other chemical compounds

HPLC and GC-MS revealed that X1 and X2 are not lanosterol and 24,25-epoxylanosterol, respectively [5].

Analytical, diagnostic and therapeutic context of 24,25-Oxidolanosterol

Although 24(S),25-oxidolanosterol does not appear to accumulate in these cell cultures, it was found in human liver in about one-fifth the amount of 24(S),25-epoxycholesterol [3].

References

An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast. Gardner, R.G., Shan, H., Matsuda, S.P., Hampton, R.Y. J. Biol. Chem. (2001) [Pubmed]
Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 24(S),25-oxidolanosterol. Panini, S.R., Delate, T.A., Sinensky, M. J. Biol. Chem. (1992) [Pubmed]
24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase. Taylor, F.R., Kandutsch, A.A., Gayen, A.K., Nelson, J.A., Nelson, S.S., Phirwa, S., Spencer, T.A. J. Biol. Chem. (1986) [Pubmed]
24,25-epoxysterols. Differentiation of 24R and 24S epimers by 13C nuclear magnetic resonance spectroscopy. Emmons, G.T., Wilson, W.K., Schroepfer, G.J. J. Lipid Res. (1989) [Pubmed]
Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines. Cytotoxicity and cholesterogenesis. Behr, P., Kupferberg, A., Leray, C., Urban, P.F., Mersel, M. FEBS Lett. (1991) [Pubmed]

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