Gene Review:
ERG1 - squalene monooxygenase
Saccharomyces cerevisiae S288c
Synonyms:
SE, Squalene epoxidase, Squalene monooxygenase, YGR175C
- Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Shibata, N., Arita, M., Misaki, Y., Dohmae, N., Takio, K., Ono, T., Inoue, K., Arai, H. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Characterization of Squalene Epoxidase of Saccharomyces cerevisiae by Applying Terbinafine-Sensitive Variants. Ruckenstuhl, C., Lang, S., Poschenel, A., Eidenberger, A., Baral, P.K., Koh??t, P., Hapala, I., Gruber, K., Turnowsky, F. Antimicrob. Agents Chemother. (2007)
- Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Gachotte, D., Barbuch, R., Gaylor, J., Nickel, E., Bard, M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. Germann, M., Gallo, C., Donahue, T., Shirzadi, R., Stukey, J., Lang, S., Ruckenstuhl, C., Oliaro-Bosso, S., McDonough, V., Turnowsky, F., Balliano, G., Nickels, J.T. J. Biol. Chem. (2005)
- A yeast strain lacking lipid particles bears a defect in ergosterol formation. Sorger, D., Athenstaedt, K., Hrastnik, C., Daum, G. J. Biol. Chem. (2004)
- ERG1, encoding squalene epoxidase, is located on the right arm of chromosome VII of Saccharomyces cerevisiae. Landl, K.M., Klösch, B., Turnowsky, F. Yeast (1996)
- A novel sequence element is involved in the transcriptional regulation of expression of the ERG1 (squalene epoxidase) gene in Saccharomyces cerevisiae. Leber, R., Zenz, R., Schröttner, K., Fuchsbichler, S., Pühringer, B., Turnowsky, F. Eur. J. Biochem. (2001)
- Single amino acid exchanges in FAD-binding domains of squalene epoxidase of Saccharomyces cerevisiae lead to either loss of functionality or terbinafine sensitivity. Ruckenstuhl, C., Eidenberger, A., Lang, S., Turnowsky, F. Biochem. Soc. Trans. (2005)
- Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles. Leber, R., Landl, K., Zinser, E., Ahorn, H., Spök, A., Kohlwein, S.D., Turnowsky, F., Daum, G. Mol. Biol. Cell (1998)
- Terbinafine: a review of its use in onychomycosis in adults. Darkes, M.J., Scott, L.J., Goa, K.L. American journal of clinical dermatology. (2003)
- Effect of detergents on sterol synthesis in a cell-free system of yeast. Hata, S., Nishino, T., Ariga, N., Katsuki, H. J. Lipid Res. (1982)
- Targeting of proteins involved in sterol biosynthesis to lipid particles of the yeast Saccharomyces cerevisiae. Müllner, H., Zweytick, D., Leber, R., Turnowsky, F., Daum, G. Biochim. Biophys. Acta (2004)
- Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. Smith, W.L., Edlind, T.D. Antimicrob. Agents Chemother. (2002)
- A Small Subpopulation of Blastospores in Candida albicans Biofilms Exhibit Resistance to Amphotericin B Associated with Differential Regulation of Ergosterol and {beta}-1,6-Glucan Pathway Genes. Khot, P.D., Suci, P.A., Miller, R.L., Nelson, R.D., Tyler, B.J. Antimicrob. Agents Chemother. (2006)
- Oxygen consumption by anaerobic Saccharomyces cerevisiae under enological conditions: effect on fermentation kinetics. Rosenfeld, E., Beauvoit, B., Blondin, B., Salmon, J.M. Appl. Environ. Microbiol. (2003)
- Regulation of squalene synthetase and squalene epoxidase activities in Saccharomyces cerevisiae. M'Baya, B., Fegueur, M., Servouse, M., Karst, F. Lipids (1989)
- An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast. Gardner, R.G., Shan, H., Matsuda, S.P., Hampton, R.Y. J. Biol. Chem. (2001)
- Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans. Favre, B., Ryder, N.S. Gene (1997)