Gene Review:
ERG7 - lanosterol synthase ERG7
Saccharomyces cerevisiae S288c
Synonyms:
2,3-epoxysqualene--lanosterol cyclase, Lanosterol synthase, OSC, Oxidosqualene--lanosterol cyclase, YHR072W
- Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae. Oliaro-Bosso, S., Ceruti, M., Balliano, G., Milla, P., Rocco, F., Viola, F. Lipids (2005)
- Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae. Shi, Z., Buntel, C.J., Griffin, J.H. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase. Corey, E.J., Matsuda, S.P., Bartel, B. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen. Corey, E.J., Matsuda, S.P., Bartel, B. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. Germann, M., Gallo, C., Donahue, T., Shirzadi, R., Stukey, J., Lang, S., Ruckenstuhl, C., Oliaro-Bosso, S., McDonough, V., Turnowsky, F., Balliano, G., Nickels, J.T. J. Biol. Chem. (2005)
- In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity. Mo, C., Milla, P., Athenstaedt, K., Ott, R., Balliano, G., Daum, G., Bard, M. Biochim. Biophys. Acta (2003)
- Site-saturated mutagenesis of histidine 234 of saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions. Wu, T.K., Liu, Y.T., Chang, C.H., Yu, M.T., Wang, H.J. J. Am. Chem. Soc. (2006)
- Tryptophan 232 within Oxidosqualene-Lanosterol Cyclase from Saccharomyces cerevisiae Influences Rearrangement and Deprotonation but Not Cyclization Reactions. Wu, T.K., Yu, M.T., Liu, Y.T., Chang, C.H., Wang, H.J., Diau, E.W. Org. Lett. (2006)
- Sequence of the Candida albicans erg7 gene. Roessner, C.A., Min, C., Hardin, S.H., Harris-Haller, L.W., McCollum, J.C., Scott, A.I. Gene (1993)
- 19-Azasqualene-2,3-epoxide and its N-oxide: metabolic fate and inhibitory effect on sterol biosynthesis in Saccharomyces cerevisiae. Milla, P., Viola, F., Ceruti, M., Rocco, F., Cattel, L., Balliano, G. Lipids (1999)
- Flux of sterol intermediates in a yeast strain deleted of the lanosterol C-14 demethylase Erg11p. Ott, R.G., Athenstaedt, K., Hrastnik, C., Leitner, E., Bergler, H., Daum, G. Biochim. Biophys. Acta (2005)
- Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast. Milla, P., Viola, F., Oliaro Bosso, S., Rocco, F., Cattel, L., Joubert, B.M., LeClair, R.J., Matsuda, S.P., Balliano, G. Lipids (2002)
- Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. Milla, P., Athenstaedt, K., Viola, F., Oliaro-Bosso, S., Kohlwein, S.D., Daum, G., Balliano, G. J. Biol. Chem. (2002)
- An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast. Gardner, R.G., Shan, H., Matsuda, S.P., Hampton, R.Y. J. Biol. Chem. (2001)
- Regulation of ergosterol biosynthesis and sterol uptake in a sterol-auxotrophic yeast. Lorenz, R.T., Parks, L.W. J. Bacteriol. (1987)
- Structural discrimination in the sparking function of sterols in the yeast Saccharomyces cerevisiae. Lorenz, R.T., Casey, W.M., Parks, L.W. J. Bacteriol. (1989)
- Lanosterol synthase in dicotyledonous plants. Suzuki, M., Xiang, T., Ohyama, K., Seki, H., Saito, K., Muranaka, T., Hayashi, H., Katsube, Y., Kushiro, T., Shibuya, M., Ebizuka, Y. Plant Cell Physiol. (2006)
- Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants. Zhang, H., Shibuya, M., Yokota, S., Ebizuka, Y. Biol. Pharm. Bull. (2003)
- Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach. Oliaro-Bosso, S., Schulz-Gasch, T., Balliano, G., Viola, F. Chembiochem (2005)