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Chemical Compound Review

Lopac-N-7778     7-nitro-1H-indazole

Synonyms: Tocris-0602, PubChem14009, CHEMBL247378, SureCN216995, CCRIS 3309, ...
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High impact information on NSC 72843

  • No significant changes occurred in glomerular filtration rate, effective renal plasma flow, urinary Na excretion, or urine volume because of 7NI [1].
  • However, plasma renin activity decreased significantly in DR and DS rats on low Na intake with 7NI infusion [1].
  • Resting ChBF was reduced and systemic blood pressure was increased after L-NAME administration, but both were unchanged after 7NI or vehicle were administered [2].
  • Evidence is provided that AngII and 7NI modulate thermoregulation primarily via AT(1) and AT(2) receptors, with predominance of AT(2) signaling following LTHA and/or hypohydration, opposing a drop in AT(1)-mediated thresholds [3].
  • 7NI alone caused some increase in levels of dopamine and a decrease in the metabolite DOPAC, which is consistent with it also acting as an inhibitor of monoamine oxidase-B [4].


  1. Role of neuronal nitric oxide synthase in Dahl salt-sensitive hypertension. Tan, D.Y., Meng, S., Manning, R.D. Hypertension (1999) [Pubmed]
  2. Neural nitric oxide mediates Edinger-Westphal nucleus evoked increase in choroidal blood flow in the pigeon. Zagvazdin, Y.S., Fitzgerald, M.E., Sancesario, G., Reiner, A. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  3. Heat acclimation affects the neuromodulatory role of AngII and nitric oxide during combined heat and hypohydration stress. Schwimmer, H., Gerstberger, R., Horowitz, M. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  4. Inhibition of the neuronal isoform of nitric oxide synthase significantly attenuates 1-methyl-4-phenylpyridinium (MPP(+)) toxicity in vitro. O'Byrne, M.B., Tipton, K.F. Journal of neural transmission (Vienna, Austria : 1996) (2002) [Pubmed]
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