Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Nor-udca (3R)-3-[ (3R,5S,7S,8S,9S,10S,13R,14S,17 R)-3...

Synonyms: CHEMBL1254990, CHEBI:804459, FT-0673148, AC1L4U0K, Norursodeoxycholic Acid, ...

Schteingart, C.D. et al., Fickert, P. et al.

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Disease relevance of Nor-udca

CONCLUSIONS: 24-norUrsodeoxycholic acid ameliorates sclerosing cholangitis in Mdr2(-/-) mice [1].
24-Norursodeoxycholic acid (nor-UDCA), when administered into the anesthetized biliary fistula hamster or injected into the perfusate of an isolated liver, was hydroxylated at C-5 to give 5 beta-hydroxynorursodeoxycholic acid 2 (3 alpha,5,7 beta-trihydroxy-24-nor-5 beta-cholan-23-oic acid), which was secreted into bile mainly as such [2].

High impact information on Nor-udca

24-norUrsodeoxycholic acid underwent extensive phase I/II metabolism (hydroxylation, sulfation, and glucuronidation), thereby increasing the hydrophilicity of biliary bile acid secretion [1].
RESULTS: 24-norUrsodeoxycholic acid markedly improved liver tests and liver histology and significantly reduced hydroxyproline content and the number of infiltrating neutrophils and proliferating hepatocytes and cholangiocytes [1].

References

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Fickert, P., Wagner, M., Marschall, H.U., Fuchsbichler, A., Zollner, G., Tsybrovskyy, O., Zatloukal, K., Liu, J., Waalkes, M.P., Cover, C., Denk, H., Hofmann, A.F., Jaeschke, H., Trauner, M. Gastroenterology (2006) [Pubmed]
5 beta-hydroxylation by the liver. Identification of 3,5,7-trihydroxy nor-bile acids as new major biotransformation products of 3,7-dihydroxy nor-bile acids in rodents. Schteingart, C.D., Hagey, L.R., Setchell, K.D., Hofmann, A.F. J. Biol. Chem. (1993) [Pubmed]

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