Gene Review:
Abcb4 - ATP-binding cassette, sub-family B...
Mus musculus
Synonyms:
ATP-binding cassette sub-family B member 4, Mdr2, Multidrug resistance protein 2, Multidrug resistance protein 3, P-glycoprotein 2, ...
Kruit,
Plösch,
Havinga,
Boverhof,
Groot,
Groen,
Kuipers,
Kok,
Bloks,
Wolters,
Havinga,
Jansen,
Staels,
Kuipers,
Kok,
Wolters,
Bloks,
Havinga,
Jansen,
Staels,
Kuipers,
Voshol,
Havinga,
Wolters,
Ottenhoff,
Princen,
Oude Elferink,
Groen,
Kuipers,
Elferink,
Ottenhoff,
Fricker,
Seward,
Ballatori,
Boyer,
Voshol,
Minich,
Havinga,
Elferink,
Verkade,
Groen,
Kuipers,
- 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Fickert, P., Wagner, M., Marschall, H.U., Fuchsbichler, A., Zollner, G., Tsybrovskyy, O., Zatloukal, K., Liu, J., Waalkes, M.P., Cover, C., Denk, H., Hofmann, A.F., Jaeschke, H., Trauner, M. Gastroenterology (2006)
- Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Fickert, P., Fuchsbichler, A., Wagner, M., Zollner, G., Kaser, A., Tilg, H., Krause, R., Lammert, F., Langner, C., Zatloukal, K., Marschall, H.U., Denk, H., Trauner, M. Gastroenterology (2004)
- Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals. Borst, P., Schinkel, A.H., Smit, J.J., Wagenaar, E., Van Deemter, L., Smith, A.J., Eijdems, E.W., Baas, F., Zaman, G.J. Pharmacol. Ther. (1993)
- Effect of Adenovirus-Mediated RNA Interference on Endogenous MicroRNAs in a Mouse Model of Multidrug Resistance Protein 2 Gene Silencing. Narvaiza, I., Aparicio, O., Vera, M., Razquin, N., Bortolanza, S., Prieto, J., Fortes, P. J. Virol. (2006)
- Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. Popov, Y., Patsenker, E., Fickert, P., Trauner, M., Schuppan, D. J. Hepatol. (2005)
- Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Kikuchi, S., Hata, M., Fukumoto, K., Yamane, Y., Matsui, T., Tamura, A., Yonemura, S., Yamagishi, H., Keppler, D., Tsukita, S., Tsukita, S. Nat. Genet. (2002)
- Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Ruetz, S., Gros, P. Cell (1994)
- Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Smit, J.J., Schinkel, A.H., Oude Elferink, R.P., Groen, A.K., Wagenaar, E., van Deemter, L., Mol, C.A., Ottenhoff, R., van der Lugt, N.M., van Roon, M.A. Cell (1993)
- The role of bile salt composition in liver pathology of mdr2 (-/-) mice: differences between males and females. van Nieuwerk, C.M., Groen, A.K., Ottenhoff, R., van Wijland, M., van den Bergh Weerman, M.A., Tytgat, G.N., Offerhaus, J.J., Oude Elferink, R.P. J. Hepatol. (1997)
- Effect of mdr2 mutation with combined tandem disruption of canalicular glycoprotein transporters by cyclosporine A on bile formation in mice. Elamiri, A., Perwaiz, S., Tuchweber, B., Yousef, I.M. Pharmacol. Res. (2003)
- Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation in Mdr2+/- mice. Hoekstra, H., Porte, R.J., Tian, Y., Jochum, W., Stieger, B., Moritz, W., Slooff, M.J., Graf, R., Clavien, P.A. Hepatology (2006)
- Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Raymond, M., Rose, E., Housman, D.E., Gros, P. Mol. Cell. Biol. (1990)
- The inability of the mouse mdr2 gene to confer multidrug resistance is linked to reduced drug binding to the protein. Buschman, E., Gros, P. Cancer Res. (1994)
- Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. Kok, T., Bloks, V.W., Wolters, H., Havinga, R., Jansen, P.L., Staels, B., Kuipers, F. Biochem. J. (2003)
- Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice. Voshol, P.J., Havinga, R., Wolters, H., Ottenhoff, R., Princen, H.M., Oude Elferink, R.P., Groen, A.K., Kuipers, F. Gastroenterology (1998)
- Natural phosphatidylcholine is actively translocated across the plasma membrane to the surface of mammalian cells. Kälin, N., Fernandes, J., Hrafnsdóttir, S., van Meer, G. J. Biol. Chem. (2004)
- mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. Buschman, E., Arceci, R.J., Croop, J.M., Che, M., Arias, I.M., Housman, D.E., Gros, P. J. Biol. Chem. (1992)
- Overexpression of the multidrug resistance-associated protein (MRP) gene in vincristine but not doxorubicin-selected multidrug-resistant murine erythroleukemia cells. Slapak, C.A., Fracasso, P.M., Martell, R.L., Toppmeyer, D.L., Lecerf, J.M., Levy, S.B. Cancer Res. (1994)
- Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice. Voshol, P.J., Minich, D.M., Havinga, R., Elferink, R.P., Verkade, H.J., Groen, A.K., Kuipers, F. Gastroenterology (2000)
- Colcemid resistance in murine SEWA cells: non-Pgy gene amplification at low levels of resistance and preferential Pgy2 gene amplification at high levels of resistance. Wettergren, Y., Kullberg, A., Levan, G. Hereditas (1995)
- Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Fickert, P., Zollner, G., Fuchsbichler, A., Stumptner, C., Pojer, C., Zenz, R., Lammert, F., Stieger, B., Meier, P.J., Zatloukal, K., Denk, H., Trauner, M. Gastroenterology (2001)
- Decreased Na+-dependent taurocholate uptake and low expression of the sinusoidal Na+-taurocholate cotransporting protein (Ntcp) in livers of mdr2 P-glycoprotein-deficient mice. Koopen, N.R., Wolters, H., Voshol, P., Stieger, B., Vonk, R.J., Meier, P.J., Kuipers, F., Hagenbuch, B. J. Hepatol. (1999)
- Structural and functional characterization of the mouse multidrug resistance gene family. Dhir, R., Buschman, E., Gros, P. Bulletin du cancer. (1990)
- Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Kruit, J.K., Plösch, T., Havinga, R., Boverhof, R., Groot, P.H., Groen, A.K., Kuipers, F. Gastroenterology (2005)
- Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis. De Vree, J.M., Ottenhoff, R., Bosma, P.J., Smith, A.J., Aten, J., Oude Elferink, R.P. Gastroenterology (2000)
- Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. Igolnikov, A.C., Green, R.M. J. Hepatol. (2006)
- Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse. Kok, T., Wolters, H., Bloks, V.W., Havinga, R., Jansen, P.L., Staels, B., Kuipers, F. Gastroenterology (2003)
- Relationship between expression of P-glycoprotein and efficacy of trifluoperazine in multidrug-resistant cells. Ganapathi, R., Kuo, T., Teeter, L., Grabowski, D., Ford, J. Mol. Pharmacol. (1991)
- Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters. Elferink, R.P., Ottenhoff, R., Fricker, G., Seward, D.J., Ballatori, N., Boyer, J. Am. J. Physiol. Gastrointest. Liver Physiol. (2004)
- Multidrug resistance gene expression during the murine ontogeny. Schiengold, M., Schwantes, L., Schwartsmann, G., Chies, J.A., Nardi, N.B. Mech. Ageing Dev. (2001)
- Amplification of the murine mdr2 gene and a reconsideration of the structure of the murine mdr gene locus. Kirschner, L.S. DNA Cell Biol. (1995)
- Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy. Crawford, A.R., Smith, A.J., Hatch, V.C., Oude Elferink, R.P., Borst, P., Crawford, J.M. J. Clin. Invest. (1997)