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Chemical Compound Review

AG-F-65740     (2S)-2-amino-4-[[(2S)-2- aminobutanoyl]...

Synonyms: AC1L4VZT, CTK8E7293, AR-1J3577, l-|A-glutamyl-n-[(2s)-2-aminobutanoyl]glycine
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High impact information on Ophthalmic acid


Gene context of Ophthalmic acid

  • The activity of glutathione synthetase from bovine lens was examined as a functions of the concentration of L-gamma-glutamyl-L-alpha-aminobutyrate, the dipeptide substrate required in the formation of ophthalmic acid [6].


  1. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. Soga, T., Baran, R., Suematsu, M., Ueno, Y., Ikeda, S., Sakurakawa, T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T., Tomita, M. J. Biol. Chem. (2006) [Pubmed]
  2. Transport of the glutathione-methylmercury complex across liver canalicular membranes on reduced glutathione carriers. Dutczak, W.J., Ballatori, N. J. Biol. Chem. (1994) [Pubmed]
  3. Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes. Ballatori, N., Dutczak, W.J. J. Biol. Chem. (1994) [Pubmed]
  4. Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. Huang, C.S., Chang, L.S., Anderson, M.E., Meister, A. J. Biol. Chem. (1993) [Pubmed]
  5. Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Lou, H., Ookhtens, M., Stolz, A., Kaplowitz, N. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  6. Glutathathione synthetase of bovine lens: anomalies of the enzyme-catalyzed formation of ophthalmic acid. Sethna, S.S., Gander, J.E., Rathbun, W.B. Curr. Eye Res. (1984) [Pubmed]
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