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Chemical Compound Review:

Proclavaminate (2S,3R)-5-amino-3-hydroxy-2- (2-oxoazetidin...

Synonyms: SureCN4094685, CHEBI:15425, AR-1G7059, AC1L4Z73, AC1Q6EZ7, ...

Wu, T.K. et al., Iwata-Reuyl, D. et al., Ahn, H.J. et al., Jensen, S.E. et al.

Jensen, Wong, Griffin, Barton,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Proclavaminate

Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene [1].

High impact information on Proclavaminate

Its binuclear manganese cluster is highly similar but not identical to the clusters of arginase and proclavaminate amidinohydrolase [2].
Proclavaminate amidino hydrolase (PAH) catalyzes the reaction of guanidinoproclavaminic acid to proclavaminic acid and urea, a central step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid [3].
In the presence of dioxygen it catalyzes the oxidative cyclization/desaturation of proclavaminic acid to clavaminic acid in a two-step process [4].

References

Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene. Jensen, S.E., Wong, A., Griffin, A., Barton, B. Antimicrob. Agents Chemother. (2004) [Pubmed]
Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily. Ahn, H.J., Kim, K.H., Lee, J., Ha, J.Y., Lee, H.H., Kim, D., Yoon, H.J., Kwon, A.R., Suh, S.W. J. Biol. Chem. (2004) [Pubmed]
Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis. Wu, T.K., Busby, R.W., Houston, T.A., McIlwaine, D.B., Egan, L.A., Townsend, C.A. J. Bacteriol. (1995) [Pubmed]
Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase. Iwata-Reuyl, D., Basak, A., Silverman, L.S., Engle, C.A., Townsend, C.A. J. Nat. Prod. (1993) [Pubmed]

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