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Chemical Compound Review

SureCN9067315     (2S,3Z,5S)-3-(2- aminoethylidene)-7-oxo-4...

Synonyms: CHEBI:15423, AC1NUT6Y, C06660, Clavaminic acid
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Disease relevance of Clavaminic acid

  • Purification and characterization of clavaminate synthase from Streptomyces antibioticus. A multifunctional enzyme of clavam biosynthesis [1].

High impact information on Clavaminic acid


Chemical compound and disease context of Clavaminic acid


Biological context of Clavaminic acid

  • ORFs encoded within the region included ones with similarity to beta-lactam synthase and clavaminic acid synthase, as well as amino acid synthesis enzymes [6].

Associations of Clavaminic acid with other chemical compounds


  1. Purification and characterization of clavaminate synthase from Streptomyces antibioticus. A multifunctional enzyme of clavam biosynthesis. Janc, J.W., Egan, L.A., Townsend, C.A. J. Biol. Chem. (1995) [Pubmed]
  2. Expression and purification of two isozymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification. Busby, R.W., Chang, M.D., Busby, R.C., Wimp, J., Townsend, C.A. J. Biol. Chem. (1995) [Pubmed]
  3. Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus. Mosher, R.H., Paradkar, A.S., Anders, C., Barton, B., Jensen, S.E. Antimicrob. Agents Chemother. (1999) [Pubmed]
  4. Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Marsh, E.N., Chang, M.D., Townsend, C.A. Biochemistry (1992) [Pubmed]
  5. Mutagenesis studies on the iron binding ligands of clavaminic acid synthase. Doan, L.X., Hassan, A., Lipscomb, S.J., Dhanda, A., Zhang, Z., Schofield, C.J. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. The biosynthetic gene cluster for the beta-lactam antibiotic tabtoxin in Pseudomonas syringae. Kinscherf, T.G., Willis, D.K. J. Antibiot. (2005) [Pubmed]
  7. Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant of the 2-His-1-carboxylate model. Khaleeli, N., Busby, R.W., Townsend, C.A. Biochemistry (2000) [Pubmed]
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