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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

BUTENOIC ACID     but-2-enoic acid

Synonyms: AGN-PC-0099XC, ACMC-1B7LD, AG-C-90662, AG-C-96479, AG-F-69342, ...
 
 
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Disease relevance of CROTONIC ACID

  • A Gram-positive spore former (Bacillus megaterium) was distinguished by an abundant peak for crotonic acid evident in positive and negative ions and not observed with M. luteus [1].
 

High impact information on CROTONIC ACID

  • The aim of this study was to investigate the equilibrium swelling properties in urea solutions of gamma-radiation induced polyelectrolyte copolymeric hydrogels consisting of acrylamide (AAm) and crotonic acid (CA) [2].
  • The butyrate enhancers acetoacetate and crotonic acid, and the butyrate unsaturated analog 2-butynoic acid, decreased methanogenesis by a maximum of 18,9 and 9%, respectively [3].
  • This in vitro evolution system consists of a polymerase chain reaction-mediated random mutagenesis and two assay procedures, a plate assay using a PHB-staining dye and a high-pressure liquid chromatographic assay based on the converting reaction from PHB to crotonic acid [4].
 

Analytical, diagnostic and therapeutic context of CROTONIC ACID

  • PHB was detected in both tetramer and monomer species of KcsA by reaction to anti-PHB IgG on Western blots, and estimated as 28 monomer units of PHB per KcsA tetramer by a chemical assay in which PHB is converted to its unique degradation product, crotonic acid [5].

References

  1. Microfabricated differential mobility spectrometry with pyrolysis gas chromatography for chemical characterization of bacteria. Schmidt, H., Tadjimukhamedov, F., Mohrenz, I.V., Smith, G.B., Eiceman, G.A. Anal. Chem. (2004) [Pubmed]
  2. Dynamic swelling behavior of gamma-radiation induced polyelectrolyte poly(AAm-co-CA) hydrogels in urea solutions. Karadağ, E., Uzüm, O.B., Saraydin, D., Güven, O. International journal of pharmaceutics. (2005) [Pubmed]
  3. Use of some novel alternative electron sinks to inhibit ruminal methanogenesis. Ungerfeld, E.M., Rust, S.R., Burnett, R. Reprod. Nutr. Dev. (2003) [Pubmed]
  4. Analysis of mutational effects of a polyhydroxybutyrate (PHB) polymerase on bacterial PHB accumulation using an in vivo assay system. Taguchi, S., Maehara, A., Takase, K., Nakahara, M., Nakamura, H., Doi, Y. FEMS Microbiol. Lett. (2001) [Pubmed]
  5. Streptomyces lividans potassium channel contains poly-(R)-3-hydroxybutyrate and inorganic polyphosphate. Reusch, R.N. Biochemistry (1999) [Pubmed]
 
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