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Chemical Compound Review:

Lom-TK-I (2S)-N-[(1S)-1-[[(1S)-1- [[(1S)-1-[[(1S)-1...

Synonyms: AR-1J1298, AC1L503S, AC1Q5JQ0, Locustatachykinin I, Tachykinin I (locusta migratoria), ...

Lundquist, C.T. et al., Pabla, N. et al., Schoofs, L. et al., Nässel, D.R. et al., Torfs, H. et al., et al.

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Disease relevance of Lom-TK-I

Two myotropic peptides termed locustatachykinin I (Gly-Pro-Ser-Gly-Phe-Tyr-Gly-Val-Arg-NH2) and locustatachykinin II (Ala-Pro-Leu-Ser-Gly-Phe-Tyr-Gly-Val-Arg-NH2) were isolated from brain-corpora cardiaca-corpora allata-suboesophageal ganglion extracts of the locust, Locusta migratoria [1].

High impact information on Lom-TK-I

Diuretic action of the peptide locustatachykinin I: cellular localisation and effects on fluid secretion in Malpighian tubules of locusts [2].
During the purification the fractions were monitored in a radioimmunoassay (RIA) with an antiserum to locust TRP locustatachykinin I (LomTK I) and a cockroach hindgut muscle contraction bioassay [3].
The glandular cells of the corpus cardiacum of the locust Locusta migratoria, known to synthesize and release adipokinetic hormones (AKH), are contacted by axons immunoreactive to an antiserum raised against the locust neuropeptide locustatachykinin I (LomTK I) [4].

Biological context of Lom-TK-I

A cockroach hindgut muscle contraction bioassay and a radioimmunoassay (RIA) employing an antiserum to locustatachykinin I (Lom TK I) were used to monitor all collected fractions [5].

Analytical, diagnostic and therapeutic context of Lom-TK-I

C-terminally (Arg to Met) substituted analogs of the insect tachykinin-related peptide, Lom-TK I, displayed increased agonistic potencies in luminescent assays for human NK1 and NK2 receptors, whereas they showed reduced potencies in the STKR-assay [6].
A radioimmunoassay was developed for insect tachykinin-related peptides with the use of an antiserum raised to the locust neuropeptide locustatachykinin I (LomTK I) [7].
Antiserum was raised against locustatachykinin I for use in immunocytochemistry [8].
Both callitachykinins were recognized by an antiserum to locustatachykinin I in enzyme-linked immunosorbent assay (ELISA) tests and callitachykinin II was additionally recognized by an antiserum to the vertebrate tachykinin kassinin, suggesting that immunolabeling of blowfly neurons with these antisera is due to neuronal callitachykinins [9].
Radioimmunoassays revealed that the female midgut contained two to three times more Lom TK I-like material than the male midgut, and radioimmunoassay coupled to high-performance liquid chromatography analysis revealed that at least five locustatachykinin isoforms appear to be present in the midgut [10].

References

Locustatachykinin I and II, two novel insect neuropeptides with homology to peptides of the vertebrate tachykinin family. Schoofs, L., Holman, G.M., Hayes, T.K., Nachman, R.J., De Loof, A. FEBS Lett. (1990) [Pubmed]
Diuretic action of the peptide locustatachykinin I: cellular localisation and effects on fluid secretion in Malpighian tubules of locusts. Johard, H.A., Coast, G.M., Mordue, W., Nässel, D.R. Peptides (2003) [Pubmed]
Seven tachykinin-related peptides isolated from the brain of the Madeira cockroach: evidence for tissue-specific expression of isoforms. Muren, J.E., Nässel, D.R. Peptides (1997) [Pubmed]
Evidence that locustatachykinin I is involved in release of adipokinetic hormone from locust corpora cardiaca. Nässel, D.R., Passier, P.C., Elekes, K., Dircksen, H., Vullings, H.G., Cantera, R. Regul. Pept. (1995) [Pubmed]
Two novel tachykinin-related peptides from the nervous system of the crab Cancer borealis. Christie, A.E., Lundquist, C.T., Nässel, D.R., Nusbaum, M.P. J. Exp. Biol. (1997) [Pubmed]
Analysis of C-terminally substituted tachykinin-like peptide agonists by means of aequorin-based luminescent assays for human and insect neurokinin receptors. Torfs, H., Detheux, M., Oonk, H.B., Akerman, K.E., Poels, J., Loy, T.V., Loof, A.D., Vassart, G., Parmentier, M., Broeck, J.V. Biochem. Pharmacol. (2002) [Pubmed]
Radioimmunoassay determination of tachykinin-related peptide in different portions of the central nervous system and intestine of the cockroach Leucophaea maderae. Muren, J.E., Nässel, D.R. Brain Res. (1996) [Pubmed]
Insect myotropic peptides: differential distribution of locustatachykinin- and leucokinin-like immunoreactive neurons in the locust brain. Nässel, D.R. Cell Tissue Res. (1993) [Pubmed]
Callitachykinin I and II, two novel myotropic peptides isolated from the blowfly, Calliphora vomitoria, that have resemblances to tachykinins. Lundquist, C.T., Clottens, F.L., Holman, G.M., Nichols, R., Nachman, R.J., Nässel, D.R. Peptides (1994) [Pubmed]
The distribution and myotropic activity of locustatachykinin-like peptides in locust midgut. Pabla, N., Lange, A.B. Peptides (1999) [Pubmed]

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