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MeSH Review

Neurosecretory Systems

 
 
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Disease relevance of Neurosecretory Systems

  • Multiple endocrine neoplasia type 1 (MEN1) consists of benign, and sometimes malignant, tumors (often multiple in a tissue) of the parathyroids, enteropancreatic neuroendocrine system, anterior pituitary, and other tissues [1].
  • In contrast, the serum CT-pr level was frequently elevated in the absence of a detectable CT level in patients with various malignant tumors and, particularly, in those with either tumors of the neuroendocrine system (60%) or hepatocellular carcinomas (62%) [2].
  • Thus, we examined in lactating rats the response of the magnocellular neuroendocrine system to dehydration and the role of endogenous opioid peptides in regulating OT release during suckling under conditions of altered fluid balance in conscious and urethane-anesthetized rats [3].
  • The resultant hyperprolactinemia may be initiated by a reduction in the release of DA from the hyothalamus, perhaps reflecting a role for milk-derived PRL in the functional development of this neurosecretory system, and maintained in part by a reduction in pituitary responsiveness to DA [4].
  • Mechanisms governing the effect of polychlorinated biphenyl (PCB) toxicity on hypothalamic serotonergic function and the neuroendocrine system controlling LH secretion were investigated in Atlantic croaker (Micropogonias unulatus) exposed to the PCB mixture Aroclor 1254 (1 microg x g body weight(-1) x day(-1)) in the diet for 30 days [5].
 

Psychiatry related information on Neurosecretory Systems

 

High impact information on Neurosecretory Systems

  • Glucocorticoids are the main effector end point of this neuroendocrine system and, through the glucocorticoid receptor, have multiple effects on immune cells and molecules [7].
  • Studies in the early to mid 1980s demonstrated that monocyte-derived or recombinant interleukin-1 (IL-1) causes secretion of hormones of the hypothalamic-pituitary-adrenal (HPA) axis, establishing that immunoregulators, known as cytokines, play a pivotal role in this bidirectional communication between the immune and neuroendocrine systems [8].
  • We propose that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin [9].
  • Glucagon-like immunoreactivity in insect corpus cardiacum [10].
  • In primates the LHRH neurosecretory system is already active during the neonatal period but subsequently enters a dormant state in the juvenile/prepubertal period [11].
 

Chemical compound and disease context of Neurosecretory Systems

 

Biological context of Neurosecretory Systems

 

Anatomical context of Neurosecretory Systems

 

Associations of Neurosecretory Systems with chemical compounds

 

Gene context of Neurosecretory Systems

 

Analytical, diagnostic and therapeutic context of Neurosecretory Systems

References

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  3. Endogenous opioid peptides inhibit oxytocin release in the lactating rat after dehydration and urethane. Hartman, R.D., Rosella-Dampman, L.M., Summy-Long, J.Y. Endocrinology (1987) [Pubmed]
  4. Hyperprolactinemia after neonatal prolactin (PRL) deficiency in rats: evidence for altered anterior pituitary regulation of PRL secretion. Shah, G.V., Shyr, S.W., Grosvenor, C.E., Crowley, W.R. Endocrinology (1988) [Pubmed]
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  6. Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease. Pedersen, W.A., Culmsee, C., Ziegler, D., Herman, J.P., Mattson, M.P. J. Mol. Neurosci. (1999) [Pubmed]
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  15. Histological and histochemical study of the caudal neurosecretory system of the freshwater teleost Ompok bimaculatus (Bloch) with a note on its response to hypophysectomy and osmotic stress. Haider, S., Pandey, A.C. Journal für Hirnforschung. (1981) [Pubmed]
  16. Neuron-specific enolase is produced by neuroendocrine tumours. Tapia, F.J., Polak, J.M., Barbosa, A.J., Bloom, S.R., Marangos, P.J., Dermody, C., Pearse, A.G. Lancet (1981) [Pubmed]
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  18. A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. Chan, R.K., Brown, E.R., Ericsson, A., Kovács, K.J., Sawchenko, P.E. J. Neurosci. (1993) [Pubmed]
  19. Cloning and sequence analysis of cDNAs encoding precursors of urotensin II-alpha and -gamma. Ohsako, S., Ishida, I., Ichikawa, T., Deguchi, T. J. Neurosci. (1986) [Pubmed]
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  21. A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A. Wu, H., Mahata, S.K., Mahata, M., Webster, N.J., Parmer, R.J., O'Connor, D.T. J. Clin. Invest. (1995) [Pubmed]
  22. Enkephalin-containing peptides processed from proenkephalin significantly enhance the antibody-forming cell responses to antigens. Hiddinga, H.J., Isaak, D.D., Lewis, R.V. J. Immunol. (1994) [Pubmed]
  23. PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Hibi, K., Westra, W.H., Borges, M., Goodman, S., Sidransky, D., Jen, J. Am. J. Pathol. (1999) [Pubmed]
  24. Activation of CD8 T cells by antigen expressed in the pituitary gland. de Jersey, J., Carmignac, D., Barthlott, T., Robinson, I., Stockinger, B. J. Immunol. (2002) [Pubmed]
  25. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Bates, S.H., Dundon, T.A., Seifert, M., Carlson, M., Maratos-Flier, E., Myers, M.G. Diabetes (2004) [Pubmed]
  26. The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems. Kuiper, G.G., Shughrue, P.J., Merchenthaler, I., Gustafsson, J.A. Frontiers in neuroendocrinology. (1998) [Pubmed]
  27. Thiethylperazine; clinical antipsychotic efficacy and correlation with potency in predictive systems. Rotrosen, J., Angrist, B.M., Gershon, S., Aronson, M., Gruen, P., Sachar, E.J., Denning, R.K., Matthysse, S., Stanley, M., Wilk, S. Arch. Gen. Psychiatry (1978) [Pubmed]
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  29. gamma-Aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Mitsushima, D., Hei, D.L., Terasawa, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  30. Central peptidergic neurons are hyperactive during collateral sprouting and inhibition of activity suppresses sprouting. Watt, J.A., Moffet, C.W., Zhou, X., Short, S., Herman, J.P., Paden, C.M. J. Neurosci. (1999) [Pubmed]
  31. Gonadotropin-releasing hormone and NMDA receptor gene expression and colocalization change during puberty in female rats. Gore, A.C., Wu, T.J., Rosenberg, J.J., Roberts, J.L. J. Neurosci. (1996) [Pubmed]
  32. Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties. Sloop, K.W., Meier, B.C., Bridwell, J.L., Parker, G.E., Schiller, A.M., Rhodes, S.J. Mol. Endocrinol. (1999) [Pubmed]
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