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Chemical Compound Review

Pyromycin     methyl(1R,2R,4S)-4- [(2S,4S,5S,6S)-4...

Synonyms: Pyrromycin, SPECTRUM201604, CCRIS 2264, BSPBio_001877, KBioGR_001530, ...
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Disease relevance of MA144 T2

  • These studies confirm the greater sensitivity of nucleolar RNA synthesis to Class II anthracyclines in erythroleukemia cells and suggest that inhibition of post-transcriptional events may occur in cells exposed to PYM, MCM, and ACM but at higher concentrations than are required for inhibition of RNA synthesis [1].
  • Since then, he found numerous anthracycline compounds such as rhodomycin-, isorhodomycin- and pyrromycin-types in Streptomyces and elucidated their structures [2].

High impact information on MA144 T2


Anatomical context of MA144 T2


  1. Effect of anthracycline analogues on the appearance of newly synthesized total RNA and messenger RNA in the cytoplasm of erythroleukemia cells. Long, B.H., Willis, C.E., Prestayko, A.W., Crooke, S.T. Mol. Pharmacol. (1982) [Pubmed]
  2. New anthracycline antibiotics. Oki, T. The Japanese journal of antibiotics. (1977) [Pubmed]
  3. Inhibition of glycoprotein biosynthesis by the inducers of HL-60 cell differentiation, aclacinomycin A and marcellomycin. Morin, M.J., Sartorelli, A.C. Cancer Res. (1984) [Pubmed]
  4. Structure-activity relationship between anthracycline-induced differentiation and inhibition of glycoprotein synthesis in Friend erythroleukemia cells. Schaefer, A., Dahle, M., Radenz, G., Steinheider, G., Marquardt, H. Leukemia (1991) [Pubmed]
  5. Induction of erythroid differentiation by the anthracycline antitumor antibiotic pyrromycin. Steinheider, G., Schaefer, A., Westendorf, J., Marquardt, H. Cell Biol. Toxicol. (1988) [Pubmed]
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