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Chemical Compound Review:

LS-55817 (4R)-4-[[(2R)-2-[[(2S)-2- [[(2R)-2-[[(2S)-2...

Synonyms: BE-18257A, AC1L538B, BE 18257A, 136553-73-6

Kojiri, K. et al., Ihara, M. et al., Nakajima, S. et al.

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Disease relevance of BE 18257A

The novel endothelin (ET) receptor antagonists BE-18257A and BE-18257B were isolated from the fermentation products of Streptomyces misakiensis [1].

High impact information on BE 18257A

Two endothelin (ET)-binding inhibitors, BE-18257A and BE-18257B, which antagonized 125I-ET-1 binding to a porcine aortic smooth muscle membrane, were isolated from the mycelium of a strain of Streptomyces misakiensis [2].
The structures of novel endothelin-binding inhibitors, BE-18257A and BE-18257B, were elucidated by spectral analyses and chemical studies [3].

References

In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor. Ihara, M., Ishikawa, K., Fukuroda, T., Saeki, T., Funabashi, K., Fukami, T., Suda, H., Yano, M. J. Cardiovasc. Pharmacol. (1992) [Pubmed]
Endothelin-binding inhibitors, BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation and characterization. Kojiri, K., Ihara, M., Nakajima, S., Kawamura, K., Funaishi, K., Yano, M., Suda, H. J. Antibiot. (1991) [Pubmed]
Endothelin-binding inhibitors, BE-18257A and BE-18257B II. Structure determination. Nakajima, S., Niiyama, K., Ihara, M., Kojiri, K., Suda, H. J. Antibiot. (1991) [Pubmed]

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