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Chemical Compound Review:

LS-55815 (4R)-4-[[(2R)-2-[[(2S)-2- [[(2R,3S)-2...

Synonyms: BE-18257B, AC1L538E, BE 18257B, 136553-74-7

Syed, N. et al., Hiramatsu, T. et al., Ihara, M. et al., Donoso, M.V. et al., Kojiri, K. et al., et al.

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Disease relevance of BE-18257B

METHODS AND RESULTS: We measured plasma ET-1 concentrations by radioimmunoassay in isolated blood-perfused neonatal lamb hearts before and after 2 hours of 10 degrees C cardioplegic ischemia and examined the effects of ET-1 and the endothelin-A (ET-A) receptor antagonist BE-18257B on the postischemic recovery of isolated hearts [1].
A competitive endothelin (ET) antagonist, BE-18257B, was isolated from the fermentation products of Streptomyces misakiensis [2].

High impact information on BE-18257B

(Group 2), or after intrarenal infusion of ET-1 superimposed on BE-18257B (Group 3) [3].
The present study examined the renal actions of ET-1 after ET-A receptors were blocked by BE-18257B to unmask the functions of ET-B receptors [3].
RESULTS: In Group 1, BE-18257B infusion did not alter arterial pressure, renal blood flow (RBF), GFR or tubular function [3].
In Group 3, BE-18257B infusion significantly attenuated the decrease in RBF caused by ET-1 and increased GFR by 40% without altering arterial pressure, associated with significant diuresis and natriuresis [3].
8. The ET-1 receptor antagonists, BE-18257B and FR 139317, blocked both the ET-1-induced rise in tone and the potentiation of ATP responses in a concentration-dependent fashion [4].

Biological context of BE-18257B

CONCLUSION: Renal vasoconstriction caused by ET-1 is attenuated by ET-A receptor blockade with BE-18257B, which unmasks the hemodynamic and tubular actions of ET-B receptors [3].

Anatomical context of BE-18257B

BE-18257B also antagonizes ET-1-induced vasoconstriction in rabbit iliac artery and pressor action in rats [2].

Associations of BE-18257B with other chemical compounds

Endothelin-binding inhibitors, BE-18257A and BE-18257B II. Structure determination [5].

Gene context of BE-18257B

Endothelin-binding inhibitors, BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation and characterization [6].

Analytical, diagnostic and therapeutic context of BE-18257B

In group 2 (n = 6), 10 mumol/L of BE-18257B was given just before reperfusion [1].

References

Effects of endothelin-1 and endothelin-A receptor antagonist on recovery after hypothermic cardioplegic ischemia in neonatal lamb hearts. Hiramatsu, T., Forbess, J., Miura, T., Roth, S.J., Cioffi, M.A., Mayer, J.E. Circulation (1995) [Pubmed]
An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis. Ihara, M., Fukuroda, T., Saeki, T., Nishikibe, M., Kojiri, K., Suda, H., Yano, M. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
Renal actions of endothelin-1 under endothelin receptor blockade by BE-18257B. Syed, N., Gulmi, F.A., Chou, S.Y., Mooppan, U.M., Kim, H. J. Urol. (1998) [Pubmed]
Involvement of ETA receptors in the facilitation by endothelin-1 of non-adrenergic non-cholinergic transmission in the rat urinary bladder. Donoso, M.V., Salas, C., Sepúlveda, G., Lewin, J., Fournier, A., Huidobro-Toro, J.P. Br. J. Pharmacol. (1994) [Pubmed]
Endothelin-binding inhibitors, BE-18257A and BE-18257B II. Structure determination. Nakajima, S., Niiyama, K., Ihara, M., Kojiri, K., Suda, H. J. Antibiot. (1991) [Pubmed]
Endothelin-binding inhibitors, BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation and characterization. Kojiri, K., Ihara, M., Nakajima, S., Kawamura, K., Funaishi, K., Yano, M., Suda, H. J. Antibiot. (1991) [Pubmed]

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