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Chemical Compound Review:

polymyxin b (6R)-N-[(1S)-3-amino-1- [[(1S,2R)-1-[[(1S)...

Synonyms: Polymyxin B1, Polymyxin B(1), CHEBI:8309, LS-118120, BRN 0505906, ...

Das, S.K. et al., Selim, S. et al., Salem, E.M. et al., Wrenn, R.W. et al., Beurer, G. et al.

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Disease relevance of BRN 0505906

The synthetic product (6) exhibited an activity comparable to that of the natural polymyxin B1 against Bacillus subtilis and Staphylococcus aureus, whereas it showed only 2% of the activity to Escherichia coli2 [1].

High impact information on BRN 0505906

The molecular masses of the latter compounds are 1,184.7 and 1,202.7 Da, respectively, and their structure is similar to that of polymyxin B1, with a cyclic heptapeptide moiety attached to a tripeptide side chain and a fatty acyl residue [2].
Interaction of polymyxin B1 and polymyxin B1 nonapeptide with phosphatidic acid monolayer and bilayer membranes [3].
The differential effect of polymyxin B1 on guinea pig lung mitochondrial and microsomal glycerophosphate acyltransferase [4].
Dual calcium-dependent protein phosphorylation systems in pancreas and their differential regulation by polymyxin B1 [5].

Anatomical context of BRN 0505906

These results suggest either that the polymyxin B1 sensitivity of mitochondrial and microsomal glycerophosphate acyltransferase is different or that their accessibility to substrates is different because the two isoenzymes are located differently in the different phospholipid microenvironment of the membranes [4].

References

Synthesis of pelargonoyl-cyclic decapeptide analog of the antibiotic polymyxin B.1. Salem, E.M., El-Gammal, A.A. Die Pharmazie. (1980) [Pubmed]
Isolation and partial characterization of antagonistic peptides produced by Paenibacillus sp. strain B2 isolated from the sorghum mycorrhizosphere. Selim, S., Negrel, J., Govaerts, C., Gianinazzi, S., van Tuinen, D. Appl. Environ. Microbiol. (2005) [Pubmed]
Interaction of polymyxin B1 and polymyxin B1 nonapeptide with phosphatidic acid monolayer and bilayer membranes. Beurer, G., Warncke, F., Galla, H.J. Chem. Phys. Lipids (1988) [Pubmed]
The differential effect of polymyxin B1 on guinea pig lung mitochondrial and microsomal glycerophosphate acyltransferase. Das, S.K., Haldar, D. Lipids (1987) [Pubmed]
Dual calcium-dependent protein phosphorylation systems in pancreas and their differential regulation by polymyxin B1. Wrenn, R.W., Wooten, M.W. Life Sci. (1984) [Pubmed]

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