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Chemical Compound Review:

NSC23519 2,4-dioxo-1H-pyrimidine-5- diazonium

Synonyms: AC1L2ND8, 3240-69-5

Ohta, T. et al., Hiramoto, K. et al., Holstege, A. et al., Coates, D.A. et al., Ho, D.H. et al., et al.

Ohta, Watanabe-Akanuma, Tokishita, Yamagata,

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Disease relevance of NSC23519

5-Diazouracil in monohydrated form showed mutagenicity and cytotoxicity on Salmonella typhimurium TA98 and TA100 strains without metabolic activation, and induced mouse micronucleated peripheral reticulocytes [1].
Cell division by strains of Escherichia coli and Salmonella typhimurium is inhibited by 5-diazouracil (5-DU) [2].

High impact information on NSC23519

In blood plasma and all other organs, however, pretreatment with 5-diazouracil was followed by a 2-fold enhancement of the radioactivity contents, mostly due to the appearance of unchanged 5-fluorouracil [3].
Every type of base-pair substitutions induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) or 5-diazouracil were detected in strains WP3101P-WP3106P, while A:T-->C:G and G:C-->A:T mutations induced by MeIQ, and A:T-->C:G, G:C-->A:T, and G:C-->C:G by 5-diazouracil were not detected in pKM101-free tester strains [4].
5-diazouracil inhibits the enzyme activity with the concentration required for inhibiting 50% (IC50) of the liver enzyme being 3 microM [5].
Induction of DNA repair synthesis in isolated rat hepatocytes by 5-diazouracil and other DNA damaging compounds [6].
On the mode of action of 5-diazouracil on bacterial cell division [2].

References

Mechanisms of the DNA breaking activity of mutagenic 5-diazouracil. Hiramoto, K., Kato, T., Kikugawa, K. Mutat. Res. (1994) [Pubmed]
On the mode of action of 5-diazouracil on bacterial cell division. Coates, D.A., Rowbury, R.J. Chem. Biol. Interact. (1976) [Pubmed]
Effect of 5-diazouracil on the catabolism of circulating pyrimidines in rat liver and kidneys. Holstege, A., Pausch, J., Gerok, W. Cancer Res. (1986) [Pubmed]
Mutation spectra of chemical mutagens determined by Lac+ reversion assay with Escherichia coli WP3101P-WP3106P tester strains. Ohta, T., Watanabe-Akanuma, M., Tokishita, S., Yamagata, H. Mutat. Res. (1999) [Pubmed]
Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate. Ho, D.H., Townsend, L., Luna, M.A., Bodey, G.P. Anticancer Res. (1986) [Pubmed]
Induction of DNA repair synthesis in isolated rat hepatocytes by 5-diazouracil and other DNA damaging compounds. Andrae, U., Schwarz, L.R. Cancer Lett. (1981) [Pubmed]

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