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Chemical Compound Review:

Combelen 1-[10-(3-dimethylaminopropyl) phenothiazin...

Synonyms: Combilen, Combolen, Lopac-P-7780, Bayer 188, CHEMBL41169, ...

Hofman, W.F. et al., Park, J. et al., Hurlbut, D.B. et al., Galatos, A.D. et al.

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Disease relevance of Combelen

During cold exposure (5 C), both the propiopromazine administration and the electroanesthesia-propiopromazine treatment resulted in hypothermia which was attributed to increased peripheral and respiratory heat losses, a transient inhibition of shivering thermogenesis, and a reduction in metabolic heat production [1].

High impact information on Combelen

Determination of propionylpromazine hydrochloride in formulation matrixes using reversed-phase ion-pair small bore liquid chromatography [2].
Premedication with diazepam was associated with fewer reflux episodes than premedication with atropine and propionylpromazine [3].

Analytical, diagnostic and therapeutic context of Combelen

The propionylpromazine concentrations in plasma after intramuscular administration to horses were determined using gas chromatography with nitrogen-phosphorus detection [4].

References

Effects of electroanesthesia and a phenothiazine tranquilizer on thermoregulation in the sheep. Hofman, W.F., Riegle, G.D. Am. J. Vet. Res. (1977) [Pubmed]
Determination of propionylpromazine hydrochloride in formulation matrixes using reversed-phase ion-pair small bore liquid chromatography. Hurlbut, D.B., Primus, T.M., Goodall, M.J., Volz, S.A., Johnston, J.J. Journal of AOAC International. (1999) [Pubmed]
Gastro-oesophageal reflux during anaesthesia in the dog: the effect of preoperative fasting and premedication. Galatos, A.D., Raptopoulos, D. Vet. Rec. (1995) [Pubmed]
Metabolism and pharmacokinetic studies of propionylpromazine in horses. Park, J., Shin, Y.O., Choo, H.Y. J. Chromatogr. (1989) [Pubmed]

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