Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

NSC-63984 2-(6-aminopurin-9-yl)-5...

Synonyms: NSC-89220, CHEBI:165813, NSC-401022, NSC-627047, AC1L6LHZ, ...

Zeevi, M. et al., Person, A. et al., Lallas, G.C. et al., Vander Heyden, N. et al.

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Disease relevance of Cordycepin

However, in the presence of cordycepin (3-deoxyadenosine) which blocks viral gene transcription and cytoplasmic poly(A) synthesis, cellular protein synthesis is still efficiently inhibited in vaccinia virus-infected cells [1].
3'-Amino derivatives of 3-deoxyadenosine was analyzed for their antiviral activity toward HIV-1 and for their host cell toxicity [2].

High impact information on Cordycepin

Nuclear RNA prepared from Ad2-infected cells after a 30 min label time in the presence or absence of 3' deoxyadenosine was hybridized to and eluted from Ad2 DNA sequences in the transcription units of region E1b and region E2 [3].
In this study we used a specific polyadenylation inhibitor, cordycepin (3-deoxyadenosine), to investigate the involvement of polyadenylation in K562 cell apoptosis and drug resistance [4].

References

Inhibition of 40S--Met--tRNAfMet ribosomal initiation complex formation by vaccinia virus. Person, A., Ben-Hamida, F., Beaud, G. Nature (1980) [Pubmed]
Analogs of 3'-amino-3'-deoxyadenosine inhibit HIV-1 replication. Vander Heyden, N., Rodi, C., Ratner, L. AIDS Res. Hum. Retroviruses (1989) [Pubmed]
Nuclear RNA is spliced in the absence of poly(A) addition. Zeevi, M., Nevins, J.R., Darnell, J.E. Cell (1981) [Pubmed]
K562 cell sensitization to 5-fluorouracil- or interferon-alpha-induced apoptosis via cordycepin (3'-deoxyadenosine): fine control of cell apoptosis via poly(A) polymerase upregulation. Lallas, G.C., Courtis, N., Havredaki, M. Int. J. Biol. Markers (2004) [Pubmed]

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