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Chemical Compound Review

DESMOSINE     2-amino-6-[4-(4-amino-4- carboxy-butyl)-3,5...

Synonyms: AGN-PC-00Q6E9, SureCN12707042, AC1L1949, AC1Q5S7H, 11003-57-9
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Disease relevance of DESMOSINE

  • Aortic wall Des concentration decreased markedly during aneurysm development, reaching 3% of normal by day 14 (377 +/- 22 pmol of Des/sample on day 0 vs 9 +/- 1 pmol of Des/sample on day 14; P <.05) [1].

High impact information on DESMOSINE

  • MME(+/+) mice exposed to smoke showed elevations in PMN, DES, and HP, but no elevations were seen in MME-deficient mice [2].
  • Pretreatment with an antibody against polymorphonuclear leukocytes (PMNs) reduced lavage PMNs to undetectable levels after smoke exposure, did not affect MAC numbers, and prevented increases in lavage DES and HP [3].
  • Aortic wall concentrations of desmosine (Des) and hydroxyproline (OHP) were measured at each interval, and the expression of tropoelastin (TE), alpha1(I) procollagen (PC), and lysyl oxidase genes was evaluated by reverse transcription-polymerase chain reaction [1].


  1. Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms. Huffman, M.D., Curci, J.A., Moore, G., Kerns, D.B., Starcher, B.C., Thompson, R.W. Surgery (2000) [Pubmed]
  2. Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Churg, A., Zay, K., Shay, S., Xie, C., Shapiro, S.D., Hendricks, R., Wright, J.L. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  3. Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin. Dhami, R., Gilks, B., Xie, C., Zay, K., Wright, J.L., Churg, A. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
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