The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Lox  -  lysyl oxidase

Rattus norvegicus

Synonyms: H-rev142, Lysyl oxidase, Protein-lysine 6-oxidase, Rrg1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lox


High impact information on Lox


Chemical compound and disease context of Lox


Biological context of Lox


Anatomical context of Lox


Associations of Lox with chemical compounds

  • Dihydrotestosterone alone enhanced LOX mRNA and enzyme activity, but potentiated the effect of FSH, causing a further reduction [14].
  • Interestingly, exposure of cells to glutathione monoethyl ester, a GSH delivery system, effectively elevated cellular GSH levels and induced a dose-dependent decrease in levels of the protein species and catalytic activity of LO [1].
  • Regulation of lysyl oxidase expression in lung fibroblasts by transforming growth factor-beta 1 and prostaglandin E2 [20].
  • The increase of lysyl oxidase activity preceded the maximal increase of total lung hydroxyproline and desmosine which occurred 28 days after bleomycin instillation [8].
  • DHEA treatment increased LOX mRNA expression to more than three times the control value (P: < 0.01) [21].

Physical interactions of Lox


Enzymatic interactions of Lox


Regulatory relationships of Lox


Other interactions of Lox


Analytical, diagnostic and therapeutic context of Lox


  1. Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate. Chen, L.J., Zhao, Y., Gao, S., Chou, I.N., Toselli, P., Stone, P., Li, W. Toxicol. Sci. (2005) [Pubmed]
  2. Biochemical and immunochemical study of lysyl oxidase in experimental hepatic fibrosis in the rat. Siegel, R.C., Chen, K.H., Greenspan, J.S., Aguiar, J.M. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  3. Lysyl oxidase expression in a rat model of arterial balloon injury. Nuthakki, V.K., Fleser, P.S., Malinzak, L.E., Seymour, M.L., Callahan, R.E., Bendick, P.J., Zelenock, G.B., Shanley, C.J. J. Vasc. Surg. (2004) [Pubmed]
  4. Alteration of the connective tissue network of striated muscle in copper deficient rats. Borg, T.K., Klevay, L.M., Gay, R.E., Siegel, R., Bergin, M.E. J. Mol. Cell. Cardiol. (1985) [Pubmed]
  5. Lysyl oxidase, the extracellular matrix-forming enzyme, in rat brain injury sites. Gilad, G.M., Kagan, H.M., Gilad, V.H. Neurosci. Lett. (2001) [Pubmed]
  6. Localization and activity of lysyl oxidase within nuclei of fibrogenic cells. Li, W., Nellaiappan, K., Strassmaier, T., Graham, L., Thomas, K.M., Kagan, H.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Reduction of blood pressure and vascular collagen in hypertensive rats by beta-aminopropionitrile. Iwatsuki, K., Cardinale, G.J., Spector, S., Udenfriend, S. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  8. Collagen lysyl oxidase activity in the lung increases during bleomycin-induced lung fibrosis. Counts, D.F., Evans, J.N., Dipetrillo, T.A., Sterling, K.M., Kelley, J. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  9. Lysyl oxidase expression and collagen cross-linking during chronic adriamycin nephropathy. Di Donato, A., Ghiggeri, G.M., Di Duca, M., Jivotenko, E., Acinni, R., Campolo, J., Ginevri, F., Gusmano, R. Nephron (1997) [Pubmed]
  10. Early intervention with a potent endothelin-A/endothelin-B receptor antagonist aggravates left ventricular remodeling after myocardial infarction in rats. Oie, E., Yndestad, A., Robins, S.P., Børnerheim, R., Asberg, A., Attramadal, H. Basic Res. Cardiol. (2002) [Pubmed]
  11. Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of beta-aminopropionitrile on arteriosclerosis. Ooshima, A., Midorikawa, O. Jpn. Circ. J. (1977) [Pubmed]
  12. Lung lysyl oxidase and prolyl hydroxylase: increases induced by cadmium chloride inhalation and the effect of beta-aminopropionitrile in rats. Chichester, C.O., Palmer, K.C., Hayes, J.A., Kagan, H.M. Am. Rev. Respir. Dis. (1981) [Pubmed]
  13. Altered adhesion features and signal transduction in NRK-49F cells transformed by down-regulation of lysyl oxidase. Giampuzzi, M., Oleggini, R., Di Donato, A. Biochim. Biophys. Acta (2003) [Pubmed]
  14. Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro. Harlow, C.R., Rae, M., Davidson, L., Trackman, P.C., Hillier, S.G. Endocrinology (2003) [Pubmed]
  15. Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence. Trackman, P.C., Pratt, A.M., Wolanski, A., Tang, S.S., Offner, G.D., Troxler, R.F., Kagan, H.M. Biochemistry (1991) [Pubmed]
  16. The 3'-untranslated region of rat lysyl oxidase cDNA. Trackman, P.C., Feres-Filho, E.J., Choi, Y.J. Biochim. Biophys. Acta (1995) [Pubmed]
  17. PKC-MEK-MAPK-dependent signal transduction pathway mediates the stimulation of lysyl oxidase expression by serum and PDGF in rat aortic smooth muscle cells. Smith-Mungo, L., Kagan, H.M. J. Cell. Biochem. (2002) [Pubmed]
  18. Extracellular matrix deposition, lysyl oxidase expression, and myofibroblastic differentiation during the initial stages of cholestatic fibrosis in the rat. Desmoulière, A., Darby, I., Costa, A.M., Raccurt, M., Tuchweber, B., Sommer, P., Gabbiani, G. Lab. Invest. (1997) [Pubmed]
  19. ECM gene expression correlates with in vitro tissue growth and development in fibrin gel remodeled by neonatal smooth muscle cells. Ross, J.J., Tranquillo, R.T. Matrix Biol. (2003) [Pubmed]
  20. Regulation of lysyl oxidase expression in lung fibroblasts by transforming growth factor-beta 1 and prostaglandin E2. Boak, A.M., Roy, R., Berk, J., Taylor, L., Polgar, P., Goldstein, R.H., Kagan, H.M. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  21. Lysyl oxidase and MMP-2 expression in dehydroepiandrosterone-induced polycystic ovary in rats. Henmi, H., Endo, T., Nagasawa, K., Hayashi, T., Chida, M., Akutagawa, N., Iwasaki, M., Kitajima, Y., Kiya, T., Nishikawa, A., Manase, K., Kudo, R. Biol. Reprod. (2001) [Pubmed]
  22. Lysyl oxidase and P-ATPase-7A expression during embryonic development in the rat. Tchaparian, E.H., Uriu-Adams, J.Y., Keen, C.L., Mitchell, A.E., Rucker, R.B. Arch. Biochem. Biophys. (2000) [Pubmed]
  23. Transforming growth factor-beta 1 increases lysyl oxidase enzyme activity and mRNA in rat aortic smooth muscle cells. Shanley, C.J., Gharaee-Kermani, M., Sarkar, R., Welling, T.H., Kriegel, A., Ford, J.W., Stanley, J.C., Phan, S.H. J. Vasc. Surg. (1997) [Pubmed]
  24. Collagen production in cardiac fibroblasts during inhibition of aminopeptidase B. Lijnen, P.J., Petrov, V.V., Turner, M., Fagard, R.H. Journal of the renin-angiotensin-aldosterone system : JRAAS. (2005) [Pubmed]
  25. Modulation of lysyl oxidase by dietary copper in rats. Rucker, R.B., Romero-Chapman, N., Wong, T., Lee, J., Steinberg, F.M., McGee, C., Clegg, M.S., Reiser, K., Kosonen, T., Uriu-Hare, J.Y., Murphy, J., Keen, C.L. J. Nutr. (1996) [Pubmed]
WikiGenes - Universities