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Gene Review

Eln  -  elastin

Rattus norvegicus

Synonyms: Elastin, RATTREL11, TREL11, Trela, Trela26, ...
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Disease relevance of Eln


Psychiatry related information on Eln

  • These observations demonstrate that long-term alcohol consumption up-regulates MMP-2 activity, which is coincident with the alteration of aortic ECM composition through the degradation of vascular elastin components [6].

High impact information on Eln


Chemical compound and disease context of Eln


Biological context of Eln


Anatomical context of Eln


Associations of Eln with chemical compounds

  • Based on known tropoelastin sequences and the molecular weights of the discrete fragments, additional fragmentation of protropoelastin and/or tropoelastin most likely occurs at the lysine/alanine-enriched domains presumably involved in cross-link formation [19].
  • Since cysteine is present only in the carboxyl-terminal end of the molecule, all the data indicate that the cleavage of the elastin fragments identified in the culture are occurring at the carboxyl end of protropoelastin [19].
  • All soluble elastin components present in the medium were purified as a single peak by high performance liquid chromatography; further separation of the components was achieved by polyacrylamide gel electrophoresis and electroblotting [19].
  • METHODS: Rat MCs cultured in media containing either 8 or 35 mM glucose were seeded into culture plates with elastin-coated flexible bottoms [20].
  • Resected lungs were stained with hematoxylin and eosin, Masson's trichrome, and Van Gieson's elastin, and immunostained with antisera to interleukin (IL)-1beta, IL-8, and basic fibroblast growth factor (bFGF) [21].

Physical interactions of Eln


Enzymatic interactions of Eln


Co-localisations of Eln


Regulatory relationships of Eln


Other interactions of Eln

  • These findings indicate that endogenous TGF-beta s, in cultured LF, regulate elastin gene expression, most likely by a posttranscriptional mechanism [15].
  • These results suggest that bFGF decreases elastin transcription [16].
  • The addition of PD-98059, an inhibitor of ERK1/2 kinase, abrogates the bFGF-dependent decrease of elastin mRNA in SMC [17].
  • Elastin degradation associated with matrix metalloproteinase activity is a cell-mediated process, observed in almost all types of vascular calcification [27].
  • Using RT-PCR and specific protein assays, we demonstrated that rat aortic SMCs incubated with elastin peptides exhibited an increased expression of the 67 kDa elastin laminin receptor (ELR) and matrix metalloproteinase-2 and typical bone proteins, such as core binding factor alpha-1, osteocalcin, and alkaline phosphatase [27].

Analytical, diagnostic and therapeutic context of Eln


  1. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. DiCamillo, S.J., Carreras, I., Panchenko, M.V., Stone, P.J., Nugent, M.A., Foster, J.A., Panchenko, M.P. J. Biol. Chem. (2002) [Pubmed]
  2. Transforming growth factor-beta increases elastin production by neonatal rat lung fibroblasts. McGowan, S.E., McNamer, R. Am. J. Respir. Cell Mol. Biol. (1990) [Pubmed]
  3. Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling. Briones, A.M., González, J.M., Somoza, B., Giraldo, J., Daly, C.J., Vila, E., González, M.C., McGrath, J.C., Arribas, S.M. J. Physiol. (Lond.) (2003) [Pubmed]
  4. Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy. Dai, J., Losy, F., Guinault, A.M., Pages, C., Anegon, I., Desgranges, P., Becquemin, J.P., Allaire, E. Circulation (2005) [Pubmed]
  5. Prevention of aneurysm development and rupture by local overexpression of plasminogen activator inhibitor-1. Allaire, E., Hasenstab, D., Kenagy, R.D., Starcher, B., Clowes, M.M., Clowes, A.W. Circulation (1998) [Pubmed]
  6. Long-term alcohol consumption increases matrix metalloproteinase-2 activity in rat aorta. Partridge, C.R., Sampson, H.W., Forough, R. Life Sci. (1999) [Pubmed]
  7. Degradation of connective tissue matrices by macrophages. II. Influence of matrix composition on proteolysis of glycoproteins, elastin, and collagen by macrophages in culture. Jones, P.A., Werb, Z. J. Exp. Med. (1980) [Pubmed]
  8. The role of vascular injury and hemodynamics in rat pulmonary artery remodeling. Tanaka, Y., Schuster, D.P., Davis, E.C., Patterson, G.A., Botney, M.D. J. Clin. Invest. (1996) [Pubmed]
  9. Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions. Wilson, E., Sudhir, K., Ives, H.E. J. Clin. Invest. (1995) [Pubmed]
  10. Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. Corman, B., Duriez, M., Poitevin, P., Heudes, D., Bruneval, P., Tedgui, A., Levy, B.I. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats. Ilkiw, R., Todorovich-Hunter, L., Maruyama, K., Shin, J., Rabinovitch, M. Circ. Res. (1989) [Pubmed]
  12. Two new elastin cross-links having pyridine skeleton. Implication of ammonia in elastin cross-linking in vivo. Umeda, H., Takeuchi, M., Suyama, K. J. Biol. Chem. (2001) [Pubmed]
  13. Effect of vitamin B-6 (pyridoxine) deficiency on lung elastin cross-linking in perinatal and weanling rat pups. Myers, B.A., Dubick, M.A., Reynolds, R.D., Rucker, R.B. Biochem. J. (1985) [Pubmed]
  14. Effects of the 21-aminosteroid, U74389F, on bleomycin-induced pulmonary fibrosis in rats. McLaughlin, G.E., Frank, L. Crit. Care Med. (1994) [Pubmed]
  15. Exogenous and endogenous transforming growth factors-beta influence elastin gene expression in cultured lung fibroblasts. McGowan, S.E., Jackson, S.K., Olson, P.J., Parekh, T., Gold, L.I. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  16. Basic fibroblast growth factor decreases elastin production by neonatal rat lung fibroblasts. Brettell, L.M., McGowan, S.E. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  17. Basic fibroblast growth factor decreases elastin gene transcription in aortic smooth muscle cells. Carreras, I., Rich, C.B., Panchenko, M.P., Foster, J.A. J. Cell. Biochem. (2002) [Pubmed]
  18. Localization of elastin mRNA and TGF-beta1 in rat aorta and caudal artery as a function of age. Sauvage, M., Hinglais, N., Mandet, C., Badier, C., Deslandes, F., Michel, J.B., Jacob, M.P. Cell Tissue Res. (1998) [Pubmed]
  19. Role of tropoelastin fragmentation in elastogenesis in rat smooth muscle cells. Franzblau, C., Pratt, C.A., Faris, B., Colannino, N.M., Offner, G.D., Mogayzel, P.J., Troxler, R.F. J. Biol. Chem. (1989) [Pubmed]
  20. TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain. Riser, B.L., Ladson-Wofford, S., Sharba, A., Cortes, P., Drake, K., Guerin, C.J., Yee, J., Choi, M.E., Segarini, P.R., Narins, R.G. Kidney Int. (1999) [Pubmed]
  21. Immunohistochemical characterization of inflammatory and proliferative events during chronic rejection in rat lung allografts. Lee, A.G., Wagner, F.M., Giaid, A., Chen, M.F., Hamid, Q., Serrick, C., Shennib, H. Transplantation (1997) [Pubmed]
  22. Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification. Bailey, M., Xiao, H., Ogle, M., Vyavahare, N. Am. J. Pathol. (2001) [Pubmed]
  23. Biochemical and immunochemical study of lysyl oxidase in experimental hepatic fibrosis in the rat. Siegel, R.C., Chen, K.H., Greenspan, J.S., Aguiar, J.M. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  24. Site-specific responses to monocrotaline-induced vascular injury: evidence for two distinct mechanisms of remodeling. Tanaka, Y., Bernstein, M.L., Mecham, R.P., Patterson, G.A., Cooper, J.D., Botney, M.D. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  25. Glucocorticoid-induced tropoelastin expression is mediated via transforming growth factor-beta 3. Yee, W., Wang, J., Liu, J., Tseu, I., Kuliszewski, M., Post, M. Am. J. Physiol. (1996) [Pubmed]
  26. Elastin expression in a model of acute arterial graft rejection. Isik, F.F., Clowes, A.W., Gordon, D. Transplantation (1994) [Pubmed]
  27. Elastin-derived peptides and TGF-beta1 induce osteogenic responses in smooth muscle cells. Simionescu, A., Philips, K., Vyavahare, N. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  28. Heterogeneity of rat tropoelastin mRNA revealed by cDNA cloning. Pierce, R.A., Deak, S.B., Stolle, C.A., Boyd, C.D. Biochemistry (1990) [Pubmed]
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