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Chemical Compound Review:

Penilloate 5,5-dimethyl-2-[(2- phenylethanoylamino)met...

Synonyms: Penilloic acid, AG-J-65509, NSC-80686, NSC80686, CTK1H1063, ...

Ressler, C. et al., Knöller, J. et al., Macy, E. et al., Kiener, P.A. et al., Knöller, J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Penilloate

The reagents, penicillin, penicilloylpolylysine, benzyl penicilloate, and benzyl penilloate provide a safe and effective skin test for screening out the likelihood of severe allergic reactions to penicillin [1].

High impact information on Penilloate

RESULTS: Nuclear magnetic resonance and mass spectrometry of the newly produced penicilloate and penilloate showed no evidence of organic contamination [2].
A method is described for the determination of mezlocillin and its metabolites penicilloic acid and penilloic acid in biological fluids by high-performance liquid chromatography [3].
Decarboxylation of the penicilloic acids from benzyl-penicillin, or from phenoxymethylpenicillin, leads to epimerization (at C-5) of the penilloic acid [4].
HPLC allows the detection of all three substances together with their metabolites, penicilloate and penilloate, within 15 min [5].

References

Skin test for diagnosis of penicillin allergy--current status. Ressler, C., Mendelson, L.M. Annals of allergy. (1987) [Pubmed]
Skin testing with penicilloate and penilloate prepared by an improved method: amoxicillin oral challenge in patients with negative skin test responses to penicillin reagents. Macy, E., Richter, P.K., Falkoff, R., Zeiger, R. J. Allergy Clin. Immunol. (1997) [Pubmed]
Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures. Knöller, J., Bremm, K.D., Schönfeld, W., König, W. Antimicrob. Agents Chemother. (1986) [Pubmed]
Reversible inhibitors of penicillinases. Kiener, P.A., Waley, S.G. Biochem. J. (1978) [Pubmed]
Degradation of acylaminopenicillins with regard to their pH dependency. Knöller, J., Schönfeld, W., Bremm, K.D., König, W. Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. (1988) [Pubmed]

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