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Chemical Compound Review

Metindol     2-[1-(4- chlorophenyl)carbonyl-5- methoxy-2...

Synonyms: Artracin, Artrivia, Indocid, Indocin, Osmosin, ...
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Disease relevance of indomethacin


High impact information on indomethacin

  • The fall in single nephron GFR (SNGFR, nl.min-1) with increasing LH perfusion was unchanged after vehicle (10.9 +/- 2.8-11.2 +/- 0.8) but was blunted (P less than 0.05) by 45-55% in rats given indo (13.9 +/- 1.2-6.2 +/- 2.2) or UK (12.8 +/- 2.1-7.0 +/- 1.5) [6].
  • Indo and perhaps other NSAIDs that enter the bile may damage the mucosa, not by a direct action, but by competing for the available protective PC molecules [7].
  • Neither the rise in IL-6 nor the activation of signal transducer and activator of transcription-3 (STAT3) that is seen during liver regeneration is inhibited by indocin or the selective COX antagonists [8].
  • In contrast, indocin treatment prevents the activation of CREB by phosphorylation that occurs during hepatic regeneration [8].
  • In accordance with our hybridization results, an increase in IL-1 activity was obtained when eosinophils were stimulated with LPS and treated with indomethacine [9].

Chemical compound and disease context of indomethacin


Biological context of indomethacin


Anatomical context of indomethacin


Associations of indomethacin with other chemical compounds


Gene context of indomethacin


Analytical, diagnostic and therapeutic context of indomethacin


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