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Chemical Compound Review

Thiocitrulline     (2S)-2-amino-5- (carbamothioylamino)pentano...

Synonyms: CHEMBL93247, BSPBio_001158, KBioGR_000498, KBioSS_000498, CHEBI:252632, ...
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Disease relevance of L-thiocitrulline


High impact information on L-thiocitrulline


Chemical compound and disease context of L-thiocitrulline

  • Previous studies in this laboratory have shown that the arginine analogues L-thiocitrulline (L-TC) and L-nitroarginine methyl ester (L-NAME) have potent protective activity against sulphur mustard (HD) toxicity that was not related to their nitric oxide synthase inhibiting activities [7].

Associations of L-thiocitrulline with other chemical compounds


Gene context of L-thiocitrulline


  1. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. Frey, C., Narayanan, K., McMillan, K., Spack, L., Gross, S.S., Masters, B.S., Griffith, O.W. J. Biol. Chem. (1994) [Pubmed]
  2. Effects of selected arginine analogues on sulphur mustard toxicity in human and hairless guinea pig skin keratinocytes. Sawyer, T.W., Risk, D. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  3. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B.S., Karoui, H., Tordo, P., Pritchard, K.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. L-arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide. Didier, C., Emonet-Piccardi, N., Béani, J.C., Cadet, J., Richard, M.J. FASEB J. (1999) [Pubmed]
  5. Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric oxide synthase. Salerno, J.C., Frey, C., McMillan, K., Williams, R.F., Masters, B.S., Griffith, O.W. J. Biol. Chem. (1995) [Pubmed]
  6. Urea enhances the nerve growth factor-induced neuroprotective effect on cholinergic neurons in organotypic rat brain slices. Zassler, B., Dechant, G., Humpel, C. Neuroscience (2005) [Pubmed]
  7. Synergistic protective effects of selected arginine analogues against sulphur mustard toxicity in neuron culture. Sawyer, T.W. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  8. Calcium/calmodulin-dependent nitric oxide synthase activity in the CNS of Aplysia californica: biochemical characterization and link to cGMP pathways. Bodnárová, M., Martásek, P., Moroz, L.L. J. Inorg. Biochem. (2005) [Pubmed]
  9. Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor. Ulhaq, S., Chinje, E.C., Naylor, M.A., Jaffar, M., Stratford, I.J., Threadgill, M.D. Bioorg. Med. Chem. (1999) [Pubmed]
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