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Chemical Compound Review:

CHEMBL164131 N,N-diprop-2-enylnitrous amide

Synonyms: CCRIS 6153, NSC-37648, LS-7130, NSC37648, NSC 37648, ...

Bauman, P.A. et al., Pour, P.M. et al., Grandjean, C.J. et al.

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Disease relevance of N-Nitrosodiallylamine

Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively [1].

High impact information on N-Nitrosodiallylamine

Single and multiple intragastric doses of diallylnitrosamine [(DAN) CAS: 16338-97-9] administered to Syrian golden hamsters induced tumors, primarily of the respiratory tract, in which the nasal cavity epithelium was the preferred site [2].
These data indicate that the allyl group of N-nitrosodiallylamine is readily oxidized by hepatocytes in vitro [3].

Associations of N-Nitrosodiallylamine with other chemical compounds

Isolated rat hepatocytes were incubated with approximately equimolar amounts of N-nitrosodi-n-propylamine (NDPA) and N-nitrosodiallylamine (NDAA) in order to compare their metabolism [3].

References

Selective induction of nasal cavity tumors in rats by diallylnitrosamine. Pour, P.M., Grandjean, C.J., Knepper, S. J. Cancer Res. Clin. Oncol. (1985) [Pubmed]
Carcinogenicity of diallylnitrosamine following intragastric administration to Syrian hamsters. Grandjean, C.J., Althoff, J., Pour, P.M. J. Natl. Cancer Inst. (1985) [Pubmed]
Metabolism of N-nitrosodi-n-propylamine and N-nitrosodiallylamine by isolated rat hepatocytes. Bauman, P.A., Hotchkiss, J.H., Parker, R.S. Cancer Lett. (1985) [Pubmed]

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