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Chemical Compound Review

AC1MHEKS     (2-pyrrolidin-1-ylcyclohexyl) N-(4...

Synonyms: AG-H-98739, CTK5H9683, KB-220334, K-2002, K 2002, ...
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Psychiatry related information on K-2002

  • Together, the data are inconsistent with [Wilkinson, L., Scholey, A. & Wesnes, K. (2002). Chewing gum selectively improves aspects of memory in healthy volunteers. Appetite, 38, 235-236.] claim that chewing gum aids immediate recall of visually presented words [1].

High impact information on K-2002

  • We recently analyzed the GPIT subunit Gaa1, a polytopic protein with seven transmembrane (TM) spans, to identify sequence determinants in the protein that are required for its interaction with other subunits and for function (Vainauskas, S., Maeda, Y., Kurniawan, H., Kinoshita, T., and Menon, A. K. (2002) J. Biol. Chem. 277, 30535-30542) [2].
  • We addressed the role of these residues in HCV RNA replication using a HCV replicon system derived from an M1LE isolate (Kishine, H., Sugiyama, K., Hijikata, M., Kato, N., Takahashi, H., Noshi, T., Nio, Y., Hosaka, M., Miyanari, Y., and Shimotohno, K. (2002) Biochem. Biophys. Res. Commun. 293, 993-999) [3].
  • In a recent study, we reported that in bovine brain extract, glycogen synthase kinase-3beta and tau are parts of an approximately 400-500 kDa microtubule-associated tau phosphorylation complex (Sun, W., Qureshi, H. Y., Cafferty, P. W., Sobue, K., Agarwal-Mawal, A., Neufield, K. D., and Paudel, H. K. (2002) J. Biol. Chem. 277, 11933-11940) [4].
  • The N-terminal synaptotagmin-like protein (Slp) homology domain (SHD) of the Slp and Slac2 families has recently been identified as a specific Rab27A-binding domain (Kuroda, T. S., Fukuda, M., Ariga, H., and Mikoshiba, K. (2002) J. Biol. Chem. 277, 9212-9218; Fukuda, M., Kuroda, T. S., and Mikoshiba, K. (2002) J. Biol. Chem. 277, 12432-12436) [5].
  • Previously, we showed that the N-terminal Slp homology domain of Slp4-a interacts with the GTP-bound form of Rab3A, Rab8, and Rab27A both in vitro and in intact cells (Kuroda, T. S., Fukuda, M., Ariga, H., and Mikoshiba, K. (2002) J. Biol. Chem. 277, 9212-9218) [6].

Biological context of K-2002

  • The 20S proteasome, the catalytic core of the 26S proteasome, has previously been isolated, purified and partially characterised from ostrich skeletal muscle (Thomas, A.R., Oosthuizen, V., Naude, R.J., Muramoto, K. 2002. Biol. Chem. 383, 1267-1270) [7].

Anatomical context of K-2002

  • Immucillins are logically designed transition-state analogue inhibitors of mammalian purine nucleoside phosphorylase (PNP) that induce purine-less death of Plasmodium falciparum in cultured erythrocytes (Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Schramm, V. L., and Kim, K. (2002) J. Biol. Chem. 277, 3226-3231) [8].

Gene context of K-2002

  • This contribution of coenzyme binding energy to domain dynamics in CPR agrees with conclusions from previous temperature-jump studies [Gutierrez, A., Paine, M., Wolf, C. R., Scrutton, N. S., and Roberts, G. C. K. (2002) Biochemistry 41, 4626-4637] [9].
  • The interaction of DEC1 with BMAL1 has been suggested as one of the molecular mechanisms of the suppression [Honma, S., Kawamoto, T., Takagi, Y., Fujimoto, K., Sato, F., Noshiro, M., Kato, Y. & Honma, K. (2002) Nature 419, 841-844] [10].
  • -to: Pani MA, Van Autreve J, Van Der Auwera BJ, Gorus FK, Badenhoop K (2002) Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules. Diabetologia 45:1340-1343 [11].


  1. Chewing gum and context-dependent memory effects: A re-examination. Miles, C., Johnson, A.J. Appetite (2007) [Pubmed]
  2. A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase. Vainauskas, S., Menon, A.K. J. Biol. Chem. (2004) [Pubmed]
  3. Mutational Analysis of Hepatitis C Virus NS5B in the Subgenomic Replicon Cell Culture. Ma, Y., Shimakami, T., Luo, H., Hayashi, N., Murakami, S. J. Biol. Chem. (2004) [Pubmed]
  4. 14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex. Agarwal-Mawal, A., Qureshi, H.Y., Cafferty, P.W., Yuan, Z., Han, D., Lin, R., Paudel, H.K. J. Biol. Chem. (2003) [Pubmed]
  5. Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A. Fukuda, M. J. Biol. Chem. (2002) [Pubmed]
  6. Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells. Fukuda, M., Kanno, E., Saegusa, C., Ogata, Y., Kuroda, T.S. J. Biol. Chem. (2002) [Pubmed]
  7. Differential effects of detergents, fatty acids, cations and heating on ostrich skeletal muscle 20S proteasome. Thomas, A.R., Oosthuizen, V., Naudé, R.J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]
  8. Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum. Kicska, G.A., Tyler, P.C., Evans, G.B., Furneaux, R.H., Kim, K., Schramm, V.L. J. Biol. Chem. (2002) [Pubmed]
  9. Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase. Grunau, A., Paine, M.J., Ladbury, J.E., Gutierrez, A. Biochemistry (2006) [Pubmed]
  10. Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Sato, F., Kawamoto, T., Fujimoto, K., Noshiro, M., Honda, K.K., Honma, S., Honma, K., Kato, Y. Eur. J. Biochem. (2004) [Pubmed]
  11. -to: Pani MA, Van Autreve J, Van Der Auwera BJ, Gorus FK, Badenhoop K (2002) Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules. Diabetologia 45:1340-1343. Hermann, R., Veijola, R., Sipilä, I., Knip, M., Akerblom, H.K., Simell, O., Ilonen, J. Diabetologia (2003) [Pubmed]
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