Disease relevance of Arinamine

• The percentage of activated eosinophils identified by staining with EG2 antibody was compared with the nasal symptoms (nasal obstruction, nasal discharge, headache, problems of smell and overall), the CT images and the olfactory dysfunction assessed using the T&T olfactometry kit and the Alinamin test [1].
• Oral administration of TPD eliminated lateral rectus palsy in patients with Wernicke's encephalopathy [2].

Psychiatry related information on Arinamine

• We injected Alinamin (thiamine propyldisulphide) into healthy subjects according to a standard protocol for clinical intravenous olfaction testing and we simultaneously recorded potential changes at the frontal scalp [3].

High impact information on Arinamine

• The intravenous olfaction test using prosultiamine (PST) solution is simple to perform and has been used clinically in Japan. We monitored intranasal intensity of smell continuously in real time under various conditions of administration using metal oxide semiconductor odor sensors and established an optimal PST injection procedure [4].
• When Alinamin was injected into the right median cubital vein over a 20 s period, the potential changes with gamma-band oscillations were detected 17.6 +/- 6.7 s (mean +/- SD) after the start of the injection [3].
• TPD induced ERD in the left temporal, parietal and occipital lobes, while TTFD induced ERD in the right temporal, parietal and occipital lobes [5].
• Significance of intravenous olfaction test using thiamine propyldisulfide (Alinamin) in olfactometry [6].
• 2) Blast injection method using an applicator permeated with Alinamin solution [7].

Anatomical context of Arinamine

• Oral administration of lipid-soluble allithiamines [thiamine propyl disulfide (TPD) and thiamine tetrahydrofurfuryl disulfide (TTHF)] rapidly increased thiamine activity in whole blood, red blood cells, cerebrospinal fluid, and urine in normal and thiamine-deficient subjects [2].

Analytical, diagnostic and therapeutic context of Arinamine

• These findings suggest that olfactory mucosal biopsy and the Alinamin intravenous injection test are useful methods of determining the prognosis in post-URVI olfactory disorders [8].
• In this preliminary study we recorded electroencephalograms (EEGs) in normal subjects during three stages: 1) eyes-closed rest (prestimulus), 2) olfactory sensation after TPD injection, and 3) disappearance of sensation [9].
• It was considered that the Alinamin test is useful not only for estimating the degree of olfactory disorders, but also for differential diagnosis of impaired lesions and olfactory prognosis [6].
• Clinical history, physical examination, and smell testing by intravenous injection of combined vitamins (Alinamin trade mark, Takeda Pharmaceutical Co. Ltd., Japan) confirmed the disease in each affected member [10].

References