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MeSH Review

Nasal Obstruction

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Disease relevance of Nasal Obstruction


High impact information on Nasal Obstruction

  • To test the hypothesis that activation of receptors in the nasal passage may be involved in reflex initiation of oral breathing after nasal obstruction, we investigated respiratory responses to nasal occlusion before and after topical lignocaine anaesthesia of the nasal passages [6].
  • Main outcome measures were clinician- and patient-rated individual and total nasal symptom scores (based on ratings of nasal obstruction, sneezing, nasal itching, and rhinorrhea); clinician-rated overall response to therapy; changes in nasal inflammatory cell counts; adverse events; and morning plasma cortisol concentrations [7].
  • Improvement in sleep quality and daytime drowsiness in patients with allergic rhinitis treated with nasal corticosteroids was reported to correlate with reduction in nasal obstruction [8].
  • CONCLUSION: In subjects with allergen-induced SAR symptoms, desloratadine significantly reduced the severity of nasal obstruction and accompanying complaints of nasal congestion and other SAR symptoms compared with the effects of placebo [9].
  • If nasal obstruction is the main problem after steroid treatment, surgical treatment is indicated [10].

Chemical compound and disease context of Nasal Obstruction


Biological context of Nasal Obstruction


Anatomical context of Nasal Obstruction


Gene context of Nasal Obstruction

  • Nasal obstruction and other symptoms of allergic rhinitis could explain some of the cognitive patterns observed in ADHD, which might result from sleep disturbance known to occur with allergic rhinitis [25].
  • RESULTS: In patients whose nasal obstruction responded to IT, TARC decreased significantly with IT, while when response was defined in terms of sneezing or rhinorrhea, TARC did not change significantly [26].
  • CONCLUSIONS: Local pretreatment with exogenous NPY reduces nasal obstruction and mucus secretion evoked by allergen challenge in allergic patients without modification of local itching and number of sneezes [27].
  • In infected subjects, there was significant rank correlation between nasal obstruction severity, rhinorrhea severity, and nasal-wash albumin concentrations and the change in IL-8 concentration from baseline on days 2-4 after virus challenge [28].
  • A single vasoactive dose of CGRP, which achieved nasal fluid concentrations similar to those elicited by antigen challenge, elicited the sensation of nasal obstruction in most subjects at 1 hr and for up to 4 hr after CGRP, without elevating nasal fluid concentrations of histamine [29].

Analytical, diagnostic and therapeutic context of Nasal Obstruction


  1. Visualization techniques in the nasal airway: their role in the diagnosis of upper airway disease and measurement of therapeutic response. Selner, J.C. J. Allergy Clin. Immunol. (1988) [Pubmed]
  2. The role of allergy in sinusitis in adults. Spector, S.L. J. Allergy Clin. Immunol. (1992) [Pubmed]
  3. A double-blind comparison of nimesulide and mefenamic acid in the treatment of acute upper respiratory tract infections in children. Salzberg, R., Giambonini, S., Maurizio, M., Roulet, D., Zahn, J., Monti, T. Drugs (1993) [Pubmed]
  4. Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis. Grosclaude, M., Mees, K., Pinelli, M.E., Lucas, M., Van de Venne, H. Rhinology. (1997) [Pubmed]
  5. Nasopharyngeal carcinoma: the role of the dentist in assessment, early diagnosis and care before and after cancer therapy. Mackie, A.M., Epstein, J.B., Wu, J.S., Stevenson-Moore, P. Oral Oncol. (2000) [Pubmed]
  6. Effects of topical nasal anaesthesia on shift of breathing route in adults. Nishino, T., Sugiyama, A., Tanaka, A., Ishikawa, T. Lancet (1992) [Pubmed]
  7. Intranasal fluticasone propionate is more effective than terfenadine tablets for seasonal allergic rhinitis. van Bavel, J., Findlay, S.R., Hampel, F.C., Martin, B.G., Ratner, P., Field, E. Arch. Intern. Med. (1994) [Pubmed]
  8. Advances in upper airway diseases and allergen immunotherapy. Nelson, H.S. J. Allergy Clin. Immunol. (2006) [Pubmed]
  9. Effect of desloratadine versus placebo on nasal airflow and subjective measures of nasal obstruction in subjects with grass pollen-induced allergic rhinitis in an allergen-exposure unit. Horak, F., Stübner, U.P., Zieglmayer, R., Harris, A.G. J. Allergy Clin. Immunol. (2002) [Pubmed]
  10. A randomized controlled study evaluating medical treatment versus surgical treatment in addition to medical treatment of nasal polyposis. Blomqvist, E.H., Lundblad, L., Anggård, A., Haraldsson, P.O., Stjärne, P. J. Allergy Clin. Immunol. (2001) [Pubmed]
  11. Once daily intranasal fluticasone propionate (200 micrograms) reduces nasal symptoms and inflammation but also attenuates the increase in bronchial responsiveness during the pollen season in allergic rhinitis. Foresi, A., Pelucchi, A., Gherson, G., Mastropasqua, B., Chiapparino, A., Testi, R. J. Allergy Clin. Immunol. (1996) [Pubmed]
  12. Fluticasone propionate given once daily is as effective for seasonal allergic rhinitis as beclomethasone dipropionate given twice daily. Ratner, P.H., Paull, B.R., Findlay, S.R., Hampel, F., Martin, B., Kral, K.M., Rogenes, P.R. J. Allergy Clin. Immunol. (1992) [Pubmed]
  13. Role of neutral endopeptidase and kininase II on substance P-induced increase in nasal obstruction in patients with allergic rhinitis. Lurie, A., Nadel, J.A., Roisman, G., Siney, H., Dusser, D.J. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  14. Comparison of beclomethasone dipropionate aqueous nasal spray, astemizole, and the combination in the prophylactic treatment of ragweed pollen-induced rhinoconjunctivitis. Juniper, E.F., Kline, P.A., Hargreave, F.E., Dolovich, J. J. Allergy Clin. Immunol. (1989) [Pubmed]
  15. Astemizole and other H1-antihistaminic drug treatment of asthma. Holgate, S.T., Emanuel, M.B., Howarth, P.H. J. Allergy Clin. Immunol. (1985) [Pubmed]
  16. Objective monitoring of nasal patency and nasal physiology in rhinitis. Nathan, R.A., Eccles, R., Howarth, P.H., Steinsvåg, S.K., Togias, A. J. Allergy Clin. Immunol. (2005) [Pubmed]
  17. The effect of cetirizine on sulfidoleukotriene production by blood leukocytes in children with allergic rhinitis. Kalayci, O., Saraclar, Y., Adalioglu, G., Sekerel, B., Tuncer, A. Allergy (1995) [Pubmed]
  18. Oral vasoconstrictors in perennial non-allergic rhinitis. Broms, P., Malm, L. Allergy (1982) [Pubmed]
  19. Histamine and the nasal vasculature: the influence of H1 and H2-histamine receptor antagonism. Wood-Baker, R., Lau, L., Howarth, P.H. Clinical otolaryngology and allied sciences. (1996) [Pubmed]
  20. Haemophilus influenzae resides and multiplies intracellularly in human adenoid tissue as demonstrated by in situ hybridization and bacterial viability assay. Forsgren, J., Samuelson, A., Ahlin, A., Jonasson, J., Rynnel-Dagöö, B., Lindberg, A. Infect. Immun. (1994) [Pubmed]
  21. Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. Miadonna, A., Milazzo, N., Gibelli, S., Salmaso, C., Lorini, M., Tedeschi, A. Clin. Exp. Allergy (1999) [Pubmed]
  22. Association between response to decongestion testing and sensitizations and allergic inflammation. Ciprandi, G., Cirillo, I., Klersy, C., Vizzaccaro, A., Tosca, M.A., Marseglia, G.L. Ann. Allergy Asthma Immunol. (2006) [Pubmed]
  23. Substance P induced histamine release from nasal mucosa of subjects with and without allergic rhinitis. Hanf, G., Schierhorn, K., Brunnée, T., Noga, O., Verges, D., Kunkel, G. Inflamm. Res. (2000) [Pubmed]
  24. Evaluation of the dose-response relationship for intra-nasal oxymetazoline hydrochloride in normal adults. Taverner, D., Bickford, L., Shakib, S., Tonkin, A. Eur. J. Clin. Pharmacol. (1999) [Pubmed]
  25. Allergic rhinitis in children with attention-deficit/hyperactivity disorder. Brawley, A., Silverman, B., Kearney, S., Guanzon, D., Owens, M., Bennett, H., Schneider, A. Ann. Allergy Asthma Immunol. (2004) [Pubmed]
  26. Changes in thymus- and activation-regulated chemokine (TARC) associated with allergen immunotherapy in patients with perennial allergic rhinitis. Takeuchi, H., Yamamoto, Y., Kitano, H., Enomoto, T. Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología. (2005) [Pubmed]
  27. Attenuation of allergen-evoked nasal responses by local pretreatment with exogenous neuropeptide Y in atopic patients. Lacroix, J.S., Mosimann, B.L. J. Allergy Clin. Immunol. (1996) [Pubmed]
  28. Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds. Turner, R.B., Weingand, K.W., Yeh, C.H., Leedy, D.W. Clin. Infect. Dis. (1998) [Pubmed]
  29. Mediation of prolonged increases in nasal mucosal blood flow by calcitonin gene-related peptide (CGRP). Rangi, S.P., Sample, S., Serwonska, M.H., Lenahan, G.A., Goetzl, E.J. J. Clin. Immunol. (1990) [Pubmed]
  30. A randomized controlled trial of glucocorticoid prophylaxis against experimental rhinovirus infection. Farr, B.M., Gwaltney, J.M., Hendley, J.O., Hayden, F.G., Naclerio, R.M., McBride, T., Doyle, W.J., Sorrentino, J.V., Riker, D.K., Proud, D. J. Infect. Dis. (1990) [Pubmed]
  31. Induction by inhibitors of nitric oxide synthase of hyperresponsiveness in the human nasal airway. Turner, P.J., Maggs, J.R., Foreman, J.C. Br. J. Pharmacol. (2000) [Pubmed]
  32. Nasal patency in children with allergic rhinitis: correlation of objective and subjective assessments. Watson, W.T., Roberts, J.R., Becker, A.B., Gendreau-Reid, L.F., Simons, F.E. Ann. Allergy Asthma Immunol. (1995) [Pubmed]
  33. Impact and modulation of nasal obstruction. Horak, F. Allergy (2002) [Pubmed]
  34. Control of vascular permeability and vascular smooth muscle in the respiratory tract by multiple neuropeptides. Saria, A., Yan, Z., Wolf, G., Loidolt, D., Martling, C.R., Lundberg, J.M. Acta oto-laryngologica. Supplementum. (1989) [Pubmed]
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