Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-00KJ66 2-sulfanylidene-1,3- thiazolidine-4...

Synonyms: AG-E-53703, AC1MHY5V, CTK1A4565, AKOS002298899, FT-0675200, ...

Thienpont, L.M. et al., van Poucke, L. et al., Johnson, D.J. et al., Takebayashi, T. et al., Emery, M.G. et al., et al.

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High impact information on 2-thioxothiazolidine-4-carboxylic acid

The total recovery of 2.5 mg of 2-thioxothiazolidine-4-carboxylic acid/g of creatinine in spiked urine by liquid-liquid extraction combined with affinity chromatography was 48.0% (SD 2.0%, n = 8) [1].
Urinary 2-thioxothiazolidine-4-carboxylic acid is a useful indicator to assess the degree of occupational exposure to carbon disulfide [1].
Significant amounts of 2-thiothiazolidine-4 carboxylic acid were present only on day 1, suggesting that the return of in vivo CYP2E1 activity was not caused by inhibitor washout, but by enzyme resynthesis [2].
The measurement of 2-thiothiazolidine-4-carboxylic acid as an index of the in vivo release of CS2 by dithiocarbamates [3].
The ability to release CS2 was assessed by measuring urinary 2-thiothiazolidine-4-carboxylic acid (TTCA), which is used in industry to measure the exposure of workers to CS2 [3].

Biological context of 2-thioxothiazolidine-4-carboxylic acid

Biological monitoring of carbon disulphide: kinetics of urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) in exposed workers [4].

Gene context of 2-thioxothiazolidine-4-carboxylic acid

Exposure to CS2 was assessed by determining the concentration of 2-thiothiazolidine-4-carboxylic acid (TTCA) in urine [5].
Urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) at the end of a shift as internal exposure index and the time-weighted average CS2 concentration as external exposure index were measured twice a year from 1992-1993 [6].

Analytical, diagnostic and therapeutic context of 2-thioxothiazolidine-4-carboxylic acid

Liquid chromatographic determination of 2-thioxothiazolidine-4-carboxylic acid isolated from urine by affinity chromatography on organomercurial agarose gel [1].
Automated column-switching high-performance liquid chromatography for the determination of 2-thiothiazolidine-4-carboxylic acid in urine [7].
The presence of 2-thiothiazolidine-4-carboxylic acid in urine of viscose workers was indicated by TLC, UV-spectrometry, and HPLC [8].
Biological monitoring for carbon disulphide (CS2) exposure performed using the iodine-azide test (IAT) and 2-thiothiazolidine-4-carboxylic acid (TTCA) test in urinalysis of workers with high exposure to CS2 (112-142 mg/m3, n = 34), workers with low exposure (4-7 mg/m3, n = 16), and non-exposed university workers (n = 10) [9].

References

Liquid chromatographic determination of 2-thioxothiazolidine-4-carboxylic acid isolated from urine by affinity chromatography on organomercurial agarose gel. Thienpont, L.M., Depourcq, G.C., Nelis, H.J., De Leenheer, A.P. Anal. Chem. (1990) [Pubmed]
Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans. Emery, M.G., Jubert, C., Thummel, K.E., Kharasch, E.D. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
The measurement of 2-thiothiazolidine-4-carboxylic acid as an index of the in vivo release of CS2 by dithiocarbamates. Johnson, D.J., Graham, D.G., Amarnath, V., Amarnath, K., Valentine, W.M. Chem. Res. Toxicol. (1996) [Pubmed]
Biological monitoring of carbon disulphide: kinetics of urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) in exposed workers. Chang, H.Y., Chou, T.C., Wang, P.Y., Shih, T.S. Toxicology and industrial health. (2002) [Pubmed]
Cross sectional observation of the effects of carbon disulphide on arteriosclerosis in rayon manufacturing workers. Omae, K., Takebayashi, T., Nomiyama, T., Ishizuka, C., Nakashima, H., Uemura, T., Tanaka, S., Yamauchi, T., O'Uchi, T., Horichi, Y., Sakurai, H. Occupational and environmental medicine. (1998) [Pubmed]
Lack of relationship between occupational exposure to carbon disulfide and endocrine dysfunction: a six-year cohort study of the Japanese rayon workers. Takebayashi, T., Nishiwaki, Y., Nomiyama, T., Uemura, T., Yamauchi, T., Tanaka, S., Sakurai, H., Omae, K. Journal of occupational health. (2003) [Pubmed]
Automated column-switching high-performance liquid chromatography for the determination of 2-thiothiazolidine-4-carboxylic acid in urine. Simon, P., Nicot, T. J. Chromatogr. (1993) [Pubmed]
Determination of thio compounds in urine of workers exposed to carbon disulfide. van Doorn, R., Leijdekkers, C.P., Henderson, P.T., Vanhoorne, M., Vertin, P.G. Arch. Environ. Health (1981) [Pubmed]
Accumulation of carbon disulphide metabolites. van Poucke, L., van Peteghem, C., Vanhoorne, M. International archives of occupational and environmental health. (1990) [Pubmed]

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