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Chemical Compound Review:

AC1MHYWS (5R)-3-ethylsulfanyl-6-(1- hydroxyethyl)-7...

Synonyms: Sch-29482, SureCN10402586, Sch 29482, 77646-83-4

Baughn, R.E. et al., Stobberingh, E.E. et al., Sanders, C.C. et al., Daschner, F.D. et al., Pechère, J.C. et al., et al.

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Disease relevance of Sch-29482

The present study was designed to assess the in vivo activity of Sch 29482, a new penem antibiotic, against disseminated and localized Treponema pallidum infections in rabbits [1].
Randomized groups then received 25 or 50 mg of Sch 29482 per kilogram of body weight twice a day for 7 days, two weekly injections of 200,000 U of penicillin G benzathine for comparative purposes, or no antibiotic therapy [1].
Sch 29482: comparative activity against Enterobacteriaceae multiply-resistant to beta-lactam antibiotics and mycobacteria [2].
Sch 29482: stability and inhibitory potency towards beta-lactamases from Gram-negative bacteria [3].
Susceptibility of anaerobic bacteria to Sch 29482 [4].

High impact information on Sch-29482

The in-vitro activity of Sch 34343, a derivative of Sch 29482, was assessed and compared with that of other beta-lactam antibiotics [5].
Pharmacokinetics of Sch 29482 in rats [6].
Effect of Sch 29482 on Gram-negative bacteria in broth, serum and in combination with human polymorphonuclear leukocytes [7].

References

Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection. Baughn, R.E., Adams, C., Musher, D.M. Antimicrob. Agents Chemother. (1984) [Pubmed]
Sch 29482: comparative activity against Enterobacteriaceae multiply-resistant to beta-lactam antibiotics and mycobacteria. Sanders, C.C., Sanders, W.E. J. Antimicrob. Chemother. (1982) [Pubmed]
Sch 29482: stability and inhibitory potency towards beta-lactamases from Gram-negative bacteria. Pechère, J.C., Letarte, R., Guay, R., Asselin, C., Morin, C. J. Antimicrob. Chemother. (1982) [Pubmed]
Susceptibility of anaerobic bacteria to Sch 29482. Sutter, V.L., Kwok, Y.Y., Finegold, S.M. J. Antimicrob. Chemother. (1982) [Pubmed]
Sch 34343, in-vitro antibacterial activity and beta-lactamase stability. Stobberingh, E.E., Houben, A.W., van Boven, C.P. J. Antimicrob. Chemother. (1985) [Pubmed]
Pharmacokinetics of Sch 29482 in rats. Lin, C., Kim, H., Chung, M., Symchowicz, S. J. Antimicrob. Chemother. (1982) [Pubmed]
Effect of Sch 29482 on Gram-negative bacteria in broth, serum and in combination with human polymorphonuclear leukocytes. Daschner, F.D., Langmaack, H., Bassler, M., Wais, U. J. Antimicrob. Chemother. (1982) [Pubmed]

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