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Chemical Compound Review

Siastatin B     (3S,4S,5S,6R)-6-acetamido- 4,5-dihydroxy...

Synonyms: AC1MIEAM, CHEMBL201657, AG-F-91094, S8063_SIGMA, CTK8G3096, ...
 
 
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Disease relevance of Siastatin B

  • [reaction: see text] 6-Acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)-3-piperidinecarboxylic acids (8 and 9) have been synthesized starting from natural siastatin B, a bacterial neuraminidase inhibitor isolated from Streptomyces culture in a stereospecific fashion [1].
  • Totally synthetic analogues of siastatin B. III. Trifluoroacetamide analogues having inhibitory activity for tumor metastasis [2].
  • When 4-nitrophenyloxamic acid and siastatin B, inhibitors of bacterial sialidases, and synthetic thioglycoside GM3 analogue Neu5Ac alpha-s-(2-6)Gal beta(1-4)Glc beta(1-1) ceramide, an inhibitor of influenza virus sialidase, were tested, they did not affect any activity of the rat sialidases [3].
 

High impact information on Siastatin B

References

 
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