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Chemical Compound Review:

PubChem12622 2,2,2-trifluoroethanamide

Synonyms: AGN-PC-006I3F, CHEMBL117012, NSC-9449, ACMC-1CJKM, AG-F-22635, ...

Rao, X. et al., Jeon, H.K. et al., London, R.E. et al., Kintz, P. et al., Xu, A.S. et al., et al.

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Disease relevance of NSC 9449

Effect on spontaneous metastasis of mouse Lewis lung carcinoma by a trifluoroacetamide analogue of siastatin B [1].

High impact information on NSC 9449

Determination of membrane potential and cell volume by 19F NMR using trifluoroacetate and trifluoroacetamide probes [2].
Intra/extracellular volume ratios determined on the basis of trifluoroacetamide intensity ratios were in good agreement with determinations based on measured hematocrits [2].
Trifluoroacetate and trifluoroacetamide, when added to a suspension of human red blood cells, give rise to separate 19F NMR signals from the intra- and extracellular species [3].
By contrast, trolox enhanced the production of TFAM in the presence of BSA, thus behaving as a pro-oxidant [4].
The method involves solid phase extraction on C18 sorbent and derivatization to the pentafluorobenzyl diester trifluoroacetamide derivatives [5].

Biological context of NSC 9449

The assay involves acid hydrolysis for hair, deuterated internal standards, a three-step liquid-liquid extraction, and derivatization with N,O-bis(trimethylsilyl) trifluoroacetamide plus 1% trimethylchlorosilane [6].

Associations of NSC 9449 with other chemical compounds

The method relies on ultrasonic extraction of particulate matter on filters at -8 degrees C; derivatization with O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine (PFBHA), and PFBHA along with bis (trimethylsilyl) trifluoroacetamide (BSTFA); and detection of the derivatives by gas chromatography/ion trap mass spectrometry [7].
Fluorescence quenching of tryptophan by trifluoroacetamide [8].

Analytical, diagnostic and therapeutic context of NSC 9449

A novel method has been developed to simultaneously determine and quantify seven organic UV filters employing liquid (solid)-liquid extraction, derivatization with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA) and gas chromatography with mass spectrometric detection in various environmental matrices [9].
Measurement of the diffusion of 2,2,2-trifluoroacetamide within thermoresponsive hydrogels using NMR imaging [10].

References

Effect on spontaneous metastasis of mouse Lewis lung carcinoma by a trifluoroacetamide analogue of siastatin B. Nishimura, Y., Satoh, T., Kondo, S., Takeuchi, T., Azetaka, M., Fukuyasu, H., Iizuka, Y., Shibahara, S. J. Antibiot. (1994) [Pubmed]
Determination of membrane potential and cell volume by 19F NMR using trifluoroacetate and trifluoroacetamide probes. London, R.E., Gabel, S.A. Biochemistry (1989) [Pubmed]
The phenomenon of separate intra- and extracellular resonances of difluorophosphate in 31P and 19F NMR spectra of erythrocytes. Xu, A.S., Potts, J.R., Kuchel, P.W. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1991) [Pubmed]
Modulation of the antioxidant activity of HO* scavengers by albumin binding: a 19F-NMR study. Aime, S., Digilio, G., Bruno, E., Mainero, V., Baroni, S., Fasano, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
An improved method for the measurement of the angiotensin-converting enzyme inhibitor lisinopril in human plasma by stable isotope dilution gas chromatography/negative ion chemical ionization mass spectrometry. Leis, H.J., Fauler, G., Raspotnig, G., Windischhofer, W. Rapid Commun. Mass Spectrom. (1999) [Pubmed]
Testing human hair and urine for anhydroecgonine methyl ester, a pyrolysis product of cocaine. Kintz, P., Cirimele, V., Sengler, C., Mangin, P. Journal of analytical toxicology. (1995) [Pubmed]
GC/ITMS measurement of carbonyls and multifunctional carbonyls in PM2.5 particles emitted from motor vehicles. Rao, X., Kobayashi, R., White-Morris, R., Spaulding, R., Frazey, P., Charles, M.J. Journal of AOAC International. (2001) [Pubmed]
Fluorescence quenching of tryptophan by trifluoroacetamide. Midoux, P., Wahl, P., Auchet, J.C., Monsigny, M. Biochim. Biophys. Acta (1984) [Pubmed]
Simultaneous determination of benzophenone-type UV filters in water and soil by gas chromatography-mass spectrometry. Jeon, H.K., Chung, Y., Ryu, J.C. Journal of chromatography. A. (2006) [Pubmed]
Measurement of the diffusion of 2,2,2-trifluoroacetamide within thermoresponsive hydrogels using NMR imaging. Dinarvand, R., Wood, B., D'Emanuele, A. Pharm. Res. (1995) [Pubmed]

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