Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Tribendimidin N'-[4-[[4-[[4-(1- dimethylaminoethylideneam...

Synonyms: Tribendimidine, CHEMBL427256, SureCN899015, SureCN12348241, AC1MJ6EW, ...

Xiao, S.H. et al., Xue, J. et al.

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High impact information on Tribendimidine

Single oral doses of tribendimidine (300 mg) and albendazole (400mg) were equally effective against Ascaris lumbricoides infections; cure rates were 96.0% (97/101) and 98.1% (101/103), respectively [1].
The model confirms the anthelminthic activity of albendazole, tribendimidine, and pyrantel pamoate and has the potential as a laboratory animal model to detect emerging drug resistance [2].

Analytical, diagnostic and therapeutic context of Tribendimidine

In clinical trials, a single oral dose of 400 mg tribendimidine, administered to patients infected only with N. americanus, or with N. americanus and Ancylostoma duodenalis, resulted in cure rates of 85.7% (132/154) and 89.8% (53/59), respectively [1].

References

Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Xiao, S.H., Hui-Ming, W., Tanner, M., Utzinger, J., Chong, W. Acta Trop. (2005) [Pubmed]
Necator americanus: optimization of the golden hamster model for testing anthelmintic drugs. Xue, J., Hui-Qing, Q., Jun-Ming, Y., Fujiwara, R., Zhan, B., Hotez, P., Shu-Hua, X. Exp. Parasitol. (2005) [Pubmed]

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