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Chemical Compound Review:

Nicomol [2-hydroxy-1,3,3- tris(pyridin-3...

Synonyms: Nicomolol, Nicomolum, Cholexamin, Cholexamine, SureCN26713, ...

Ikeda, S. et al., Yasui, M. et al., Shinozawa, S. et al.

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Disease relevance of Nicomol

Anti-hyperlipemic agents such as MDS, nicomol, Ino-N and Co Q10 strongly protected against the ADM-induced toxicity, and the mice administered these drugs lived significantly longer than the control mice [1].

High impact information on Nicomol

It is concluded that 2.5 mg/kg.day ibudilast plus 300 mg/kg.day nicomol or 10 mg/kg.day ibudilast produced a scavenger effect on calcium deposited in the CNS and abdominal aorta of rabbits fed a cholesterol-rich diet [2].
High density lipoprotein (HDL) fractions were separated by dextran sulfate-Mg++ from sera of 5 healthy males before and after oral administration of a daily 1200 mg dose of Nicomol (2,2,6,6-tetrakis (nicotinoyloxymethyl) cyclohexanol; Cholexamin, Kyorin Pharmaceutical Co. Ltd.) for 2 weeks [3].

References

Protection against adriamycin (doxorubicin)-induced toxicity in mice by several clinically used drugs. Shinozawa, S., Gomita, Y., Araki, Y. Acta Med. Okayama (1987) [Pubmed]
Effects of ibudilast on calcium deposition in soft tissues of rabbits with atherosclerosis. Yasui, M., Ota, K., Oshima, A. J. Int. Med. Res. (1990) [Pubmed]
Effect of nicomol on high density lipoprotein (HDL) subfractions, HDL2e and HDL3e, separated by electrophoresis. Ikeda, S., Nagashima, H., Taketa, K., Watanabe, M. Acta Med. Okayama (1981) [Pubmed]

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