Chemical Compound Review:
Eyevinal 2-methyl-1-(8-propan-2-yl- 1,9...
Synonyms:
Pinatos, ibudilast, Ibudilastum, Ketas, Lopac-I-0157, ...
- Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore. Takuma, K., Phuagphong, P., Lee, E., Mori, K., Baba, A., Matsuda, T. J. Biol. Chem. (2001)
- Ibudilast, a phosphodiesterase inhibitor, ameliorates experimental autoimmune encephalomyelitis in Dark August rats. Fujimoto, T., Sakoda, S., Fujimura, H., Yanagihara, T. J. Neuroimmunol. (1999)
- Effect of ibudilast, a novel antiasthmatic agent, on anaphylactic bronchoconstriction: predominant involvement of endogenous slow reacting substance of anaphylaxis. Ohashi, M., Uno, T., Nishino, K. Int. Arch. Allergy Immunol. (1993)
- Ibudilast protects against neuronal damage induced by glutamate in cultured hippocampal neurons. Tominaga, Y., Nakamura, Y., Tsuji, K., Shibata, T., Kataoka, K. Clin. Exp. Pharmacol. Physiol. (1996)
- Ibudilast, a phosphodiesterase inhibitor, protects against white matter damage under chronic cerebral hypoperfusion in the rat. Wakita, H., Tomimoto, H., Akiguchi, I., Lin, J.X., Ihara, M., Ohtani, R., Shibata, M. Brain Res. (2003)
- Cyclic GMP/cyclic GMP-dependent protein kinase system prevents excitotoxicity in an immortalized oligodendroglial cell line. Yoshioka, A., Yamaya, Y., Saiki, S., Kanemoto, M., Hirose, G., Pleasure, D. J. Neurochem. (2000)
- Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Mizuno, T., Kurotani, T., Komatsu, Y., Kawanokuchi, J., Kato, H., Mitsuma, N., Suzumura, A. Neuropharmacology (2004)
- Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-beta-propionaphtone hydrochloride (KZ-111) and 3-isobutyryl-2-isopropylpyrazole-[1, 5-a] pyridine (KC-404). Nagai, H., Iwamoto, T., Nishiyori, T., Takizawa, T., Tsuchiya, H., Koda, A. Jpn. J. Pharmacol. (1983)
- The role of prostanoids in the mediation of responses to KC-404, a novel cerebrovasodilator. Armstead, W.M., Mirro, R., Leffler, C.W., Busija, D.W. J. Pharmacol. Exp. Ther. (1988)
- Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Souness, J.E., Villamil, M.E., Scott, L.C., Tomkinson, A., Giembycz, M.A., Raeburn, D. Br. J. Pharmacol. (1994)
- Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model. Takuma, K., Lee, E., Enomoto, R., Mori, K., Baba, A., Matsuda, T. Br. J. Pharmacol. (2001)
- Inhibition by ibudilast of leukotriene D4-induced formation of inositol phosphates in guinea-pig lung. Etoh, S., Ohashi, M., Baba, A., Iwata, H. Br. J. Pharmacol. (1990)
- Inhibitory effect of ibudilast (KC-404) on the expression of the beta2 integrin family on an eosinophilic cell line (EoL-1). Chihara, J., Urayama, O., Kayaba, H., Honda, K., Saito, N., Hayashi, N., Kurachi, D., Yamamoto, T. Ann. Allergy Asthma Immunol. (1998)
- Relaxation and potentiation of cGMP-mediated response by ibudilast in bovine tracheal smooth muscle. Nakahara, T., Yunoki, M., Moriuchi, H., Mitani, A., Sakamoto, K., Ishii, K. Naunyn Schmiedebergs Arch. Pharmacol. (2002)
- Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis. Feng, J., Misu, T., Fujihara, K., Sakoda, S., Nakatsuji, Y., Fukaura, H., Kikuchi, S., Tashiro, K., Suzumura, A., Ishii, N., Sugamura, K., Nakashima, I., Itoyama, Y. Mult. Scler. (2004)
- Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Kishi, Y., Ohta, S., Kasuya, N., Sakita, S., Ashikaga, T., Isobe, M. Cardiovascular drug reviews. (2001)
- Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS. Suzumura, A., Ito, A., Yoshikawa, M., Sawada, M. Brain Res. (1999)
- Inhibitory effect of ibudilast on urinary albumin excretion in type 2 diabetes mellitus with microalbuminuria. Hoshino, T., Ikeda, T. Nephron (2002)
- Pharmacological effects of ibudilast on cerebral circulation: a PET study. Fukuyama, H., Kimura, J., Yamaguchi, S., Yamauchi, H., Ogawa, M., Doi, T., Yonekura, Y., Konishi, J. Neurol. Res. (1993)
- Potentiation of ibudilast inhibition of platelet aggregation in the presence of endothelial cells. Rile, G., Yatomi, Y., Qi, R., Satoh, K., Ozaki, Y. Thromb. Res. (2001)