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Chemical Compound Review:

NSC-403460 6-(hydroxymethyl)-5-methoxy- oxane-2,3,4-triol

Synonyms: NSC403460, AC1L83DK, 27552-11-0, 4-O-Methylmannose, 6-(hydroxymethyl)-5-methoxyoxane-2,3,4-triol

Yanagihara, Y. et al., Yanagihara, Y. et al.

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Disease relevance of NSC403460

Of particular interest was the presence of 4-O-methylmannose as a constituent polysaccharide in members of the genus Leptospira [1].
4-O-Methylmannose was detected in the cell wall polysaccharides of the genus Leptospira but not in cell walls prepared from the Spirochaeta, Borrelia, and Treponema [1].
Since 4-O-methylmannose and A2pm were found in the cell wall fractions of genus Leptospira but not in Spirochaeta, Borrelia, or Treponema, it was suggested that the chemical compositions of the cell wall might become an important criterion for the chemotaxonomy of Spirochaetales [1].

Anatomical context of NSC403460

Identification of 4-O-methylmannose in cell wall polysaccharide of Leptospira [2].

References

Chemical compositions of cell walls and polysaccharide fractions of spirochetes. Yanagihara, Y., Kamisango, K., Yasuda, S., Kobayashi, S., Mifuchi, I., Azuma, I., Yamamura, Y., Johnson, R.C. Microbiol. Immunol. (1984) [Pubmed]
Identification of 4-O-methylmannose in cell wall polysaccharide of Leptospira. Yanagihara, Y., Kamisango, K., Takeda, K., Mifuchi, I., Azuma, I. Microbiol. Immunol. (1983) [Pubmed]

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