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Chemical Compound Review

AKOS006346735     5-chloro-2-hydroxy-1H- pyridin-4-one

Synonyms:
 
 
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Disease relevance of Cdhp compound

 

High impact information on Cdhp compound

 

Associations of Cdhp compound with other chemical compounds

 

Gene context of Cdhp compound

  • The purpose of this study was to evaluate the use of 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of dihydropyrimidine dehydrogenase (DPD), to enhance the antitumour activity of the fluoropyrimidines [5].

References

  1. A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur. Daigo, S., Takahashi, Y., Fujieda, M., Ariyoshi, N., Yamazaki, H., Koizumi, W., Tanabe, S., Saigenji, K., Nagayama, S., Ikeda, K., Nishioka, Y., Kamataki, T. Pharmacogenetics (2002) [Pubmed]
  2. The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells. Oguri, T., Achiwa, H., Bessho, Y., Muramatsu, H., Maeda, H., Niimi, T., Sato, S., Ueda, R. Lung Cancer (2005) [Pubmed]
  3. Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer. Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., Imada, T. Oncol. Rep. (2006) [Pubmed]
  4. A case of bone metastasis of colon cancer that markedly responded to S-1/CPT-11 combination chemotherapy and became curable by resection. Mado, K., Ishii, Y., Mazaki, T., Ushio, M., Masuda, H., Takayama, T. World journal of surgical oncology [electronic resource]. (2006) [Pubmed]
  5. Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Takechi, T., Fujioka, A., Matsushima, E., Fukushima, M. Eur. J. Cancer (2002) [Pubmed]
  6. Feasibility study of adjuvant chemotherapy with S-1 (TS-1; tegafur, gimeracil, oteracil potassium) for gastric cancer. Kinoshita, T., Nashimoto, A., Yamamura, Y., Okamura, T., Sasako, M., Sakamoto, J., Kojima, H., Hiratsuka, M., Arai, K., Sairenji, M., Fukushima, N., Kimura, H., Nakajima, T. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. (2004) [Pubmed]
  7. Significance of dihydropyrimidine dehydrogenase activity in renal cell carcinoma. Mizutani, Y., Wada, H., Yoshida, O., Fukushima, M., Nakanishi, H., Nakao, M., Miki, T. Eur. J. Cancer (2003) [Pubmed]
  8. Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor agent in animal model and in patients with impaired renal function. Ikeda, M., Furukawa, H., Imamura, H., Shimizu, J., Ishida, H., Masutani, S., Tatsuta, M., Kawasaki, T., Satomi, T. Cancer Chemother. Pharmacol. (2002) [Pubmed]
  9. Chemotherapy sensitivity and resistance testing: to be "standard" or to be individualized, that is the question. Kubota, T., Weisenthal, L. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. (2006) [Pubmed]
 
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