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MeSH Review

Feasibility Studies

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Disease relevance of Feasibility Studies


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High impact information on Feasibility Studies

  • Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation (total dose, 2000 rad) in an uncontrolled feasibility study, as an alternative to long-term therapy with cytotoxic drugs such as cyclophosphamide and azathioprine [7].
  • This feasibility study demonstrates that this new self-centering atrial septal defect closure device has a number of design features that permit effective and safe closures in a canine model [8].
  • In the course of feasibility studies to examine the efficiencies and practicalities of various techniques for screening for genetic variations, the human coagulation factor IX (F9) genes of 63 Japanese families were examined by PCR-denaturing gradient gel electrophoresis (PCR-DGGE) [9].
  • OBJECTIVE: The feasibility study for the VA Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes (VA CSDM) prospectively studied 153 insulin-requiring type 2 diabetes patients, randomized between an intensively treated arm and a standard treatment arm during a mean follow-up of 27 months [10].
  • Response to intensive therapy steps and to glipizide dose in combination with insulin in type 2 diabetes. VA feasibility study on glycemic control and complications (VA CSDM) [10].

Chemical compound and disease context of Feasibility Studies


Biological context of Feasibility Studies


Anatomical context of Feasibility Studies


Associations of Feasibility Studies with chemical compounds


Gene context of Feasibility Studies


Analytical, diagnostic and therapeutic context of Feasibility Studies


  1. A feasibility study of multiple cycle therapy with melphalan, thiotepa, and paclitaxel followed by mitoxantrone, thiotepa, and paclitaxel with autologous hematopoietic cell support for metastatic breast cancer. Hu, W.W., Long, G.D., Stockerl-Goldstein, K.E., Johnston, L.J., Chao, N.J., Negrin, R.S., Blume, K.G. Clin. Cancer Res. (1999) [Pubmed]
  2. Intracellular expression of cellular eIF-5A mutants inhibits HIV-1 replication in human T cells: a feasibility study. Junker, U., Bevec, D., Barske, C., Kalfoglou, C., Escaich, S., Dobrovnik, M., Hauber, J., Böhnlein, E. Hum. Gene Ther. (1996) [Pubmed]
  3. BTS randomised feasibility study of active symptom control with or without chemotherapy in malignant pleural mesothelioma: ISRCTN 54469112. Muers, M.F., Rudd, R.M., O'Brien, M.E., Qian, W., Hodson, A., Parmar, M.K., Girling, D.J. Thorax (2004) [Pubmed]
  4. 188Re-HDD/lipiodol for treatment of hepatocellular carcinoma: a feasibility study in patients with advanced cirrhosis. Lambert, B., Bacher, K., De Keukeleire, K., Smeets, P., Colle, I., Jeong, J.M., Thierens, H., Troisi, R., De Vos, F., Van de Wiele, C. J. Nucl. Med. (2005) [Pubmed]
  5. Paclitaxel, ifosfamide and cisplatin with granulocyte colony-stimulating factor or recombinant human interleukin 3 and granulocyte colony-stimulating factor in ovarian cancer: a feasibility study. Veldhuis, G.J., Willemse, P.H., Beijnen, J.H., Boonstra, H., Piersma, H., van der Graaf, W.T., de Vries, E.G. Br. J. Cancer (1997) [Pubmed]
  6. 1H Magnetic resonance spectroscopy of the internal capsule in human brain: a feasibility study to detect lactate following contralateral motor activity. Mostert, J.P., Sijens, P.E., Oudkerk, M., De Keyser, J. European radiology. (2005) [Pubmed]
  7. Treatment of intractable rheumatoid arthritis with total lymphoid irradiation. Kotzin, B.L., Strober, S., Engleman, E.G., Calin, A., Hoppe, R.T., Kansas, G.S., Terrell, C.P., Kaplan, H.S. N. Engl. J. Med. (1981) [Pubmed]
  8. Experimental atrial septal defect closure with a new, transcatheter, self-centering device. Das, G.S., Voss, G., Jarvis, G., Wyche, K., Gunther, R., Wilson, R.F. Circulation (1993) [Pubmed]
  9. Variations among Japanese of the factor IX gene (F9) detected by PCR-denaturing gradient gel electrophoresis. Satoh, C., Takahashi, N., Asakawa, J., Hiyama, K., Kodaira, M. Am. J. Hum. Genet. (1993) [Pubmed]
  10. Response to intensive therapy steps and to glipizide dose in combination with insulin in type 2 diabetes. VA feasibility study on glycemic control and complications (VA CSDM). Abraira, C., Henderson, W.G., Colwell, J.A., Nuttall, F.Q., Comstock, J.P., Emanuele, N.V., Levin, S.R., Sawin, C.T., Silbert, C.K. Diabetes Care (1998) [Pubmed]
  11. Phase II feasibility study of high dose epirubicin plus etoposide and cisplatin (HDEEC) regimen in small cell lung cancer. Rosell, R., Carles, J., Abad, A., Jimeno, J.M., Moreno, I., Barnadas, A., Ribelles, N., Haboubi, N. Investigational new drugs. (1992) [Pubmed]
  12. Hyperproduction of tryptophan by Escherichia coli: genetic manipulation of the pathways leading to tryptophan formation. Tribe, D.E., Pittard, J. Appl. Environ. Microbiol. (1979) [Pubmed]
  13. Induction paclitaxel/carboplatin in early stage non-small cell lung cancer. Bimodality Lung Oncology Team. Pisters, K.M., Kris, M.G., Bunn, P.A., Johnson, D.H., Ruckdeschel, J.C., Crowley, J.J., Ginsberg, R.J. Semin. Oncol. (1997) [Pubmed]
  14. Full dose chemotherapy in elderly patients with non-Hodgkin's lymphoma: a feasibility study using a mitoxantrone containing regimen. Sonneveld, P., Michiels, J.J. Br. J. Cancer (1990) [Pubmed]
  15. Multi-modality megatherapy with [131I]meta-iodobenzylguanidine, high dose melphalan and total body irradiation with bone marrow rescue: feasibility study of a new strategy for advanced neuroblastoma. Gaze, M.N., Wheldon, T.E., O'Donoghue, J.A., Hilditch, T.E., McNee, S.G., Simpson, E., Barrett, A. Eur. J. Cancer (1995) [Pubmed]
  16. Single-breath inhalation induction of sevoflurane anaesthesia with and without nitrous oxide: a feasibility study in adults and comparison with an intravenous bolus of propofol. Hall, J.E., Stewart, J.I., Harmer, M. Anaesthesia. (1997) [Pubmed]
  17. A multimedia psychosocial support program for couples receiving infertility treatment: a feasibility study. Cousineau, T.M., Lord, S.E., Seibring, A.R., Corsini, E.A., Viders, J.C., Lakhani, S.R. Fertil. Steril. (2004) [Pubmed]
  18. Softwood forest thinnings as a biomass source for ethanol production: a feasibility study for California. Kadam, K.L., Wooley, R.J., Aden, A., Nguyen, Q.A., Yancey, M.A., Ferraro, F.M. Biotechnol. Prog. (2000) [Pubmed]
  19. Assessment of the classical MDR phenotype in epithelial ovarian carcinoma using primary cultures: a feasibility study. Coley, H.M., Sargent, J.M., Williamson, C.J., Titley, J., Scheper, R.J., Gregson, S.E., Elgie, A.W., Lewandowicz, G.M., Taylor, C.G. Anticancer Res. (2002) [Pubmed]
  20. The acceptability to primary care staff of a multidisciplinary training package on acute back pain guidelines. Underwood, M., O'Meara, S., Harvey, E. Family practice. (2002) [Pubmed]
  21. Induction of nuclear anomalies (micronuclei) in the peripheral blood erythrocytes of the eastern mudminnow Umbra pygmaea by ethyl methanesulphonate. Hooftman, R.N., de Raat, W.K. Mutat. Res. (1982) [Pubmed]
  22. Alpha-tocopherol supplementation for men with existing coronary artery disease: a feasibility study. Hoffman, R.M., Garewal, H.S. Preventive medicine. (1999) [Pubmed]
  23. Mapping of the cardiac sympathetic nervous system by single photon emission tomography with technetium-99m-labelled fluorobenzylpiperidine derivative (99mTc-FBPBAT): result of a feasibility study in a porcine model and an initial dosimetric estimation in humans. Richter, S., Schaefer, A., Menger, M.D., Kirsch, C.M., Samnick, S. Nuclear medicine communications. (2005) [Pubmed]
  24. Feasibility study of serial lumbar puncture and acetazolamide combination in the management of elevated cerebrospinal fluid pressure in AIDS patients with cryptococcal meningitis in Uganda. Orem, J., Tindyebwa, L., Twinoweitu, O., Mukasa, B., Tomberland, M., Mbidde, E.K. Tropical doctor. (2005) [Pubmed]
  25. Optical monitor of glucose. March, W., Engerman, R., Rabinovitch, B. Transactions - American Society for Artificial Internal Organs. (1979) [Pubmed]
  26. Imaging with 99mTc ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents. Yang, D.J., Kim, C.G., Schechter, N.R., Azhdarinia, A., Yu, D.F., Oh, C.S., Bryant, J.L., Won, J.J., Kim, E.E., Podoloff, D.A. Radiology. (2003) [Pubmed]
  27. Development and validation of a near-infrared method for the quantitation of caffeine in intact single tablets. Laasonen, M., Harmia-Pulkkinen, T., Simard, C., Räsänen, M., Vuorela, H. Anal. Chem. (2003) [Pubmed]
  28. Positron imaging feasibility studies. II: Characteristics of 2-deoxyglucose uptake in rodent and canine neoplasms: concise communication. Larson, S.M., Weiden, P.L., Grunbaum, Z., Kaplan, H.G., Rasey, J.S., Graham, M.M., Sale, G.E., Harp, G.D., Williams, D.L. J. Nucl. Med. (1981) [Pubmed]
  29. Pre-operative chemotherapy in early stage resectable non-small-cell lung cancer: a randomized feasibility study justifying a multicentre phase III trial. de Boer, R.H., Smith, I.E., Pastorino, U., O'Brien, M.E., Ramage, F., Ashley, S., Goldstraw, P. Br. J. Cancer (1999) [Pubmed]
  30. A feasibility study of 252Cf neutron brachytherapy, cisplatin + 5-FU chemo-adjuvant and accelerated hyperfractionated radiotherapy for advanced cervical cancer. Maruyama, Y., Bowen, M.G., Van Nagell, J.R., Gallion, H.H., DePriest, P., Wierzbicki, J. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  31. Technetium-99m RP527, a GRP analogue for visualisation of GRP receptor-expressing malignancies: a feasibility study. Van de Wiele, C., Dumont, F., Vanden Broecke, R., Oosterlinck, W., Cocquyt, V., Serreyn, R., Peers, S., Thornback, J., Slegers, G., Dierckx, R.A. European journal of nuclear medicine. (2000) [Pubmed]
  32. Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model. Bremer, C., Bredow, S., Mahmood, U., Weissleder, R., Tung, C.H. Radiology. (2001) [Pubmed]
  33. Real-time RT-PCR detection of CK19, CK7 and MUC1 mRNA for diagnosis of lymph node micrometastases in non small cell lung carcinoma. Saintigny, P., Coulon, S., Kambouchner, M., Ricci, S., Martinot, E., Danel, C., Breau, J.L., Bernaudin, J.F. Int. J. Cancer (2005) [Pubmed]
  34. A feasibility study of the children's medication algorithm project (CMAP) algorithm for the treatment of ADHD. Pliszka, S.R., Lopez, M., Crismon, M.L., Toprac, M.G., Hughes, C.W., Emslie, G.J., Boemer, C. Journal of the American Academy of Child and Adolescent Psychiatry. (2003) [Pubmed]
  35. Feasibility study on spray-drying protein pharmaceuticals: recombinant human growth hormone and tissue-type plasminogen activator. Mumenthaler, M., Hsu, C.C., Pearlman, R. Pharm. Res. (1994) [Pubmed]
  36. Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence. Rock, C.L., Flatt, S.W., Wright, F.A., Faerber, S., Newman, V., Kealey, S., Pierce, J.P. Cancer Epidemiol. Biomarkers Prev. (1997) [Pubmed]
  37. Ambulatory high-dose 5-day continuous-infusion ifosfamide combination chemotherapy in advanced solid tumors: a feasibility study. Loeffler, T.M., Weber, F.W., Hausamen, T.U. J. Cancer Res. Clin. Oncol. (1991) [Pubmed]
  38. Patient-controlled analgesia for labour using remifentanil: a feasibility study. Blair, J.M., Hill, D.A., Fee, J.P. British journal of anaesthesia. (2001) [Pubmed]
  39. P300 recordings during event-related fMRI: a feasibility study. Otzenberger, H., Gounot, D., Foucher, J.R. Brain research. Cognitive brain research. (2005) [Pubmed]
  40. Comparison of the acute biological action of injectable salmon calcitonin and an injectable and oral calcitonin analogue. Devogelaer, J.P., Azria, M., Attinger, M., Abbiati, G., Castiglioni, C., Nagant de Deuxchaisnes, C. Calcif. Tissue Int. (1994) [Pubmed]
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