Chemical Compound Review:
Florafur 5-fluoro-1-(oxolan-2- yl)pyrimidine-2,4-dione
Synonyms:
Ftorafur, Futraful, Fluorofur, tegafur, Sunfural S, ...
Peters,
Noordhuis,
Van Groeningen,
Giaccone,
Holwerda,
Voorn,
Schrijvers,
Schornagel,
Beijnen,
Fumoleau,
Schellens,
Ohtsu,
Shimada,
Shirao,
Boku,
Hyodo,
Saito,
Yamamichi,
Miyata,
Ikeda,
Yamamoto,
Fukuda,
Yoshida,
Ichikawa,
Uetake,
Shirota,
Yamada,
Nishi,
Nihei,
Sugihara,
Hirayama,
Noguchi,
Koyama,
Uchino,
Abe,
Miura,
Sugimachi,
Akazawa,
Abe,
Ajani,
Faust,
Ikeda,
Yao,
Anbe,
Carr,
Houghton,
Urrea,
Hoff,
Janjan,
Saad,
Skibber,
Crane,
Lassere,
Cleary,
Benner,
Randolph,
Abbruzzese,
Pazdur,
Takagi,
Inenaga,
Oya,
Nakamura,
Ikemura,
Campos,
Saniger,
Marchal,
Aiello,
Súarez,
Boulaiz,
Aránega,
A Gallo,
Espinosa,
Carmichael,
Popiela,
Radstone,
Falk,
Borner,
Oza,
Skovsgaard,
Munier,
Martin,
Ichinose,
Nakai,
Kudoh,
Semba,
Yoshida,
Nukiwa,
Yamamoto,
Yamane,
Niitani,
- Randomized clinical trial of adjuvant mitomycin plus tegafur in patients with resected stage III gastric cancer. Cirera, L., Balil, A., Batiste-Alentorn, E., Tusquets, I., Cardona, T., Arcusa, A., Jolis, L., Saigí, E., Guasch, I., Badia, A., Boleda, M. J. Clin. Oncol. (1999)
- Phase I-II studies of oral tegafur (ftorafur). Ansfield, F.J., Kallas, G.J., Singson, J.P. J. Clin. Oncol. (1983)
- Phase I study of preoperative oral uracil and tegafur plus leucovorin and radiation therapy in rectal cancer. Hoff, P.M., Janjan, N., Saad, E.D., Skibber, J., Crane, C., Lassere, Y., Cleary, K.R., Benner, S., Randolph, J., Abbruzzese, J.L., Pazdur, R. J. Clin. Oncol. (2000)
- Metabolism of 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil in mice. Fujimoto, S., Ishigami, H., Minami, T., Miyazaki, M., Itoh, K., Kimura, K. J. Natl. Cancer Inst. (1979)
- Phase I pharmacokinetic study of S-1 plus cisplatin in patients with advanced gastric carcinoma. Ajani, J.A., Faust, J., Ikeda, K., Yao, J.C., Anbe, H., Carr, K.L., Houghton, M., Urrea, P. J. Clin. Oncol. (2005)
- Postoperative adjuvant therapy with tamoxifen, tegafur plus uracil, or both in women with node-negative breast cancer: a pooled analysis of six randomized controlled trials. Noguchi, S., Koyama, H., Uchino, J., Abe, R., Miura, S., Sugimachi, K., Akazawa, K., Abe, O. J. Clin. Oncol. (2005)
- Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. Carmichael, J., Popiela, T., Radstone, D., Falk, S., Borner, M., Oza, A., Skovsgaard, T., Munier, S., Martin, C. J. Clin. Oncol. (2002)
- Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205). Ohtsu, A., Shimada, Y., Shirao, K., Boku, N., Hyodo, I., Saito, H., Yamamichi, N., Miyata, Y., Ikeda, N., Yamamoto, S., Fukuda, H., Yoshida, S. J. Clin. Oncol. (2003)
- Tegafur/uracil + calcium folinate in colorectal cancer: double modulation of fluorouracil. Hoff, P.M., Lassere, Y., Pazdur, R. Drugs (1999)
- Blood vessel density correlates with the effects of targeted intra-arterial carboplatin infusion with concurrent radiotherapy for squamous cell carcinomas of the oral cavity and oropharynx. Takagi, S., Inenaga, R., Oya, R., Nakamura, S., Ikemura, K. Br. J. Cancer (2006)
- The number of 5-fluoro-2'-deoxyuridine-5'-monophosphate binding sites and reduced folate pool in human colorectal carcinoma tissues: changes after tegafur and uracil treatment. Omura, K., Kawakami, K., Kanehira, E., Nagasato, A., Kawashima, S., Tawaraya, K., Watanabe, S., Hirano, K., Shirasaka, T., Watanabe, Y. Cancer Res. (1995)
- 5-Fluorouracil prodrug: role of anabolic and catabolic pathway modulation in therapy of colorectal cancer. Cao, S., Frank, C., Shirasaka, T., Rustum, Y.M. Clin. Cancer Res. (1995)
- Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro. Ikeda, K., Yoshisue, K., Matsushima, E., Nagayama, S., Kobayashi, K., Tyson, C.A., Chiba, K., Kawaguchi, Y. Clin. Cancer Res. (2000)
- New medium oxacyclic O,N-acetals and related open analogues: biological activities. Campos, J., Saniger, E., Marchal, J.A., Aiello, S., Súarez, I., Boulaiz, H., Aránega, A., A Gallo, M., Espinosa, A. Current medicinal chemistry. (2005)
- A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur. Daigo, S., Takahashi, Y., Fujieda, M., Ariyoshi, N., Yamazaki, H., Koizumi, W., Tanabe, S., Saigenji, K., Nagayama, S., Ikeda, K., Nishioka, Y., Kamataki, T. Pharmacogenetics (2002)
- Effect of normal allogeneic lymphoid cell transfer in combination with chemotherapy on a transplantable tumor in rats. Yamada, Y., Kawamura, T., Gotohda, E., Akiyama, J., Hosokawa, M., Kodama, T., Kobayashi, H. Cancer Res. (1980)
- Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Nakajima, Y., Gotanda, T., Uchimiya, H., Furukawa, T., Haraguchi, M., Ikeda, R., Sumizawa, T., Yoshida, H., Akiyama, S. Cancer Res. (2004)
- Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites. Haraguchi, M., Furukawa, T., Sumizawa, T., Akiyama, S. Cancer Res. (1993)
- In vitro biological evaluation of the R and S isomers of 1-(Tetrahydrofuran-2-yl)-5-fluorouracil. Horwitz, J.P., McCormick, J.J., Philips, K.D., Maher, V.M., Otto, J.R., Kessel, D., Zemlicka, J. Cancer Res. (1975)
- Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver. Komatsu, T., Yamazaki, H., Shimada, N., Nagayama, S., Kawaguchi, Y., Nakajima, M., Yokoi, T. Clin. Cancer Res. (2001)
- Uracil/tegafur plus cisplatin with concurrent radiotherapy for locally advanced non-small-cell lung cancer: a multi-institutional phase II trial. Ichinose, Y., Nakai, Y., Kudoh, S., Semba, H., Yoshida, S., Nukiwa, T., Yamamoto, H., Yamane, Y., Niitani, H. Clin. Cancer Res. (2004)
- The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors. Peters, G.J., Noordhuis, P., Van Groeningen, C.J., Giaccone, G., Holwerda, U., Voorn, D., Schrijvers, A., Schornagel, J.H., Beijnen, J.H., Fumoleau, P., Schellens, J.H. Clin. Cancer Res. (2004)
- Fluorinated pyrimidine nucleosides. 4. Synthesis and antitumor testing of a series of 2',5'-dideoxy- and 2',3',5'-trideoxynucleosides of 5-fluorouracil. Cook, A.F., Holman, M.J., Kramer, M.J. J. Med. Chem. (1980)
- Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Ichikawa, W., Uetake, H., Shirota, Y., Yamada, H., Nishi, N., Nihei, Z., Sugihara, K., Hirayama, R. Clin. Cancer Res. (2003)
- Cloning and characterization of the 5'-transcriptional regulatory region of the human intercellular adhesion molecule 1 gene. Degitz, K., Li, L.J., Caughman, S.W. J. Biol. Chem. (1991)
- Genomic organization of the rat aromatic L-amino acid decarboxylase (AADC) locus: partial analysis reveals divergence from the Drosophila dopa decarboxylase (DDC) gene structure. Hahn, S.L., Hahn, M., Joh, T.H. Mamm. Genome (1991)
- Randomized trial of adjuvant chemotherapy with mitomycin plus ftorafur versus mitomycin alone in resected locally advanced gastric cancer. Grau, J.J., Estapé, J., Fuster, J., Filella, X., Visa, J., Terés, J., Soler, G., Albiol, S., García-Valdecasas, J.C., Grande, L., Bombí, J., Bordas, J., Alcobendas, F. J. Clin. Oncol. (1998)
- Protracted oral chemotherapy with fluorinated pyrimidines as an adjuvant to surgical treatment for stomach cancer. Fujimoto, S., Akao, T., Itoh, B., Koshizuka, I., Koyano, K. Ann. Surg. (1977)